Recruiting NCT06729996
Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus
Pancreatitis, Chronic · Pancreatitis, Acute · Diabetes Mellitus
GI & liver
8,202 trials in this section
Recruiting NCT07735182
Microbiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
Sepsis · Acute Kidney Injury Due to Sepsis · Gastrointestinal Microbiome
Recruiting NCT05024097
A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
Rectal Cancer
Recruiting NCT03855917
Strategic Treatment Reduction in Very Early Liver Disease With 4 Weeks Sofosbuvir Plus Glecepravir-pibrentasvir
Hepatitis C
Recruiting NCT06519591
Systemic Application of Cadonilimab, LM-302, and S-1 Combined With Intraperitoneal Infusion of Paclitaxel for the Treatment of Claudin 18.2-positive Gastric Cancer With Peritoneal Metastasis
Gastric Cancer Stage IV · Peritoneal Metastases
Recruiting NCT07732894
Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome
Rectal Cancer · Fecal Incontinence and Constipation · Aerobic Exercise
Not yet recruiting NCT07004413
Continuous or Intermittent Cetuximab Plus FOLFIRI as First-line Treatment in RAS/BRAF Wild-type mCRC Patients
Colorectal Cancer Metastatic
Not yet recruiting NCT07732543
Developing and Testing the Effectiveness of Smart Healthcare Assisted Individualized Symptom Management Education and Home-based Exercise on Frailty, Treatment-related Adverse Events and Quality of Life in Advanced Gastric Cancer Patients Receiving Immunotherapy
Gastric Cancer (GC) · Immunotherapy
Recruiting NCT06802172
Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial
Rectal Cancer Stage II · Rectal Cancer Stage III · Breast Cancer Stage I
Recruiting NCT03190538
Nonalcoholic Steatohepatitis in Chinese Children
Non-Alcoholic Fatty Liver Disease
Recruiting NCT06253117
Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.
Recurrent Acute Pancreatitis
Recruiting NCT07195708
Orbera365 Intragastric Balloon System (Abbreviated as'Orbera365')
Weight Loss
Not yet recruiting NCT07734896
Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure
Acute-on-Chronic Liver Failure (ACLF) · Liver Cirrhosis · End Stage Liver Disease
Not yet recruiting NCT07733180
A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCC
Advanced Esophageal Squamous Cell Carcinoma · Metastatic Esophageal Squamous Cell Carcinoma
Recruiting NCT06685497
COLORECTUM+ Digital System for Postoperative Quality Improvement in Colorectal Cancer
Colorectal Carcinoma
Recruiting NCT05045482
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
Hepatic Impairment · Cirrhosis · Cholestatic Liver Disease
Recruiting NCT07321106
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer
Colorectal Cancer · Colorectal Cancer (CRC) · Colorectal (Colon or Rectal) Cancer
Not yet recruiting NCT07729917
Precision Integrated Strategies and Efficacy Evaluation for Biliary Tract Cancers: An Umbrella Platform Study
Bile Duct Carcinoma · Cholangiocarcinoma
Recruiting NCT07059494
Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant
Hepatocellular Carcinoma
Recruiting NCT04098471
Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer
Rectal Cancer
Not yet recruiting NCT07730489
A Study Comparing BL-M07D1 With Physician's Choice Therapy in Patients With HER2 IHC3+ Advanced Colorectal Cancer Who Failed Prior Treatment With Oxaliplatin, Fluorouracil and Irinotecan
Colorectal Cancer
Not yet recruiting NCT07726368
Study of ECC4703 With Sulfasalazine and Pitavastatin
Non-alcoholic Fatty Liver Disease (NAFLD) · Dyslipidaemia
Not yet recruiting NCT07727759
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Post-Hepatectomy Liver Failure · Liver Failure · Liver Neoplasms
Recruiting NCT05727176
Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement
Advanced Cholangiocarcinoma · FGFR2 Fusions · Gene Rearrangement
Recruiting NCT07255404
A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well it Works When Combined With Chemotherapy for People Who Have Not Been Treated Yet for Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDAC)
Recruiting NCT07221851
Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders
Turner Syndrome · Short Stature Homeobox Gene Mutation · Idiopathic Short Stature
Not yet recruiting NCT07580339
Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer
Rectal Cancer
Recruiting NCT06825559
Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease
Cholestatic Liver Disease
Recruiting NCT07479485
MRG006A Combination Therapy for Advanced Hepatocellular Carcinoma (Phase I/II)
Hepatocellular Carcinoma
Recruiting NCT06906887
PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer
Esophageal Cancer · Oesophageal Cancer · GastroEsophageal Cancer
Recruiting NCT04557969
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
Gastric Cancer · Gastric Neoplasm · Gastrointestinal Stromal Sarcoma
Recruiting NCT07527858
Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer
Advanced Microsatellite Stable Colorectal Cancer
Recruiting NCT07730541
Hyperpolarized 13C-MRI and Radiomics in Rectal Cancer
Neoadjuvant Chemoradiotherapy
Recruiting NCT06321081
ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC
RAS Mutation · Metastatic Colorectal Cancer · MSS
Not yet recruiting NCT07730138
Phase 3 to Evaluate the Efficacy and Safety of DWP14012 in Patients With Gastric Ulcer
Gastric Ulcer
Recruiting NCT06417892
Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma
Gastric Cancer
Not yet recruiting NCT07732075
Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 as Maintenance Therapy in Subjects With Healed Erosive Esophagitis
Maintenance of Healed Erosive Gastroesophageal Reflux Disease (ERD)
Not yet recruiting NCT07730853
Isocaloric Navy-Bean Substitution in Adults With MASLD
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) · Liver Fibrosis · Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Recruiting NCT07701486
A Study of More Frequent Dosing of VCN-01 Combined With Standard Chemotherapy in Patients With Newly Diagnosed Metastatic Pancreatic Cancer
Pancreas Cancer, Metastatic · Pancreas Cancer, Stage IV · Ductal Adenocarcinoma of the Pancreas
Recruiting NCT04877197
Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care
Depression · Cardiovascular Diseases
Recruiting NCT07486570
Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery
Mesenteric Vascular Disease · Colorectal Surgery · Preventive Intervention
Not yet recruiting NCT07729605
FOLFIRI Plus Bevacizuamb and QL1706 in Second-Line Treatment for mCRC
Colorectal Cancer Metastatic · Microsatellite Stable (MSS) Colorectal Cancer (CRC)
Not yet recruiting NCT07724951
The Efficacy and Safety of Donafenib Plus PD-1/L1 Monoclonal Antibodies Plus TACE or HAIC as First-line Treatment for Unresectable Hepatocellular Carcinoma A Multi-center, Retrospective Clinical Study
Hepatocellular Carcinoma (HCC)
Recruiting NCT07227506
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Gerd · Eosinophilic Esophagitis
Recruiting NCT06446609
Drug-induced Liver Injury: Itching Study
Drug Induced Liver Injury · Pruritus
Not yet recruiting NCT07726966
Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial
Rectum Cancer · Anastomotic Leak
Not yet recruiting NCT07727629
Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy Volunteers
Gastro Esophageal Reflux Disorder
Not yet recruiting NCT07729592
Dapagliflozin Add-on in Unresectable HCC With Metabolic Syndrome
Hepatocellular Carcinoma (HCC)
Recruiting NCT07436637
Guardant Shield Colorectal Cancer Screening
Colorectal Cancer
Not yet recruiting NCT07723664
Evaluation of SofWave Sofware-Guided Energy Delivery for Lower Face and Neck Rejuvenation
Facial Wrinkles · Jawline Contour · Skin Laxity
Recruiting NCT07221188
A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH
Non-alcoholic Fatty Liver Disease
Recruiting NCT07444541
ANO31905 in Combination With Chemotherapy for CLDN18.2-Positive Locally Advanced Unresectable or Metastatic Pancreatic Cancer
Pancreatic Cancer
Recruiting NCT07518043
A Study of HLX18 vs. OPDIVO® in Multiple Resected Solid Tumors
Esophageal and/or Cardia Cancer · Melanoma · Urothelial Carcinoma (UC)
Not yet recruiting NCT06414122
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
Oesophageal Cancer · Gastric Cancer · Duodenal Cancer
Recruiting NCT07066657
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Locally Advanced or Metastatic Solid Tumors · Colorectal Cancer · Gastric Cancer
Not yet recruiting NCT07728019
Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM
CRC (Colorectal Cancer)
Recruiting NCT07221227
A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH
Non-alcoholic Fatty Liver Disease
Recruiting NCT07607769
MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.
Hepatocellular Carcinoma
Recruiting NCT07728292
Safety and Efficacy of Underwater Endoscopic Mucosal Resection for Type I Gastric Neuroendocrine Tumors Measuring 5-9 mm
Stomach Neuroendocrine Neoplasm
Not yet recruiting NCT07727993
Neoadjuvant Propranolol Plus SOX and Toripalimab for Locally Advanced Gastric/GEJ Adenocarcinoma
Gastric or Gastroesophageal Junction Adenocarcinoma · Propranolol · SOX Chemotherapy
Recruiting NCT07409272
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
Pancreatic Cancer · Metastatic Pancreatic Cancer · Metastatic Pancreatic Adenocarcinoma
Recruiting NCT07444320
Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System
Paroxysmal Atrial Fibrillation · Persistent Atrial Fibrillation
Not yet recruiting NCT07729618
AI-Guided First-Line Immunotherapy Selection in Unresectable Hepatocellular Carcinoma
Unresectable Hepatocellular Carcinoma
Not yet recruiting NCT07689825
Development of a Risk Prediction Model for Post-Spinal Anesthesia Hypotension During Cesarean Delivery Using Heart Rate, Blood Pressure, Perfusion Index, ECG Waveforms, and SpO₂ Waveforms
Cesarean Section
Not yet recruiting NCT07729033
A Phase II Exploratory Study of Sacituzumab Tirumotecan Combined With Envafolimab for TROP2-Positive Advanced Biliary Tract Cancers Previously Treated With First-Line Immunotherapy Combined With Chemotherapy.
Advanced Biliary Tract Cancers
Recruiting NCT06593431
Extending Outcomes for Pancreas Cancer Patients With Nominal Oligometastatic Disease (EXPAND): A Randomized Phase III Trial
Pancreas Cancer · Oligometastatic
Recruiting NCT07726446
Study on Sequential Cryoablation, Relaforp Alpha, and Chemotherapy for Bile Duct Tumors
Biliary Tract Cancer (BTC)
Enrolling by invitation NCT06883838
Project CASCADE: Community and Academic Synergy for Cancer Survivorship Care Delivery Enhancement
Cancer Survivorship
Not yet recruiting NCT07726316
An Observational Study Measuring in a Non-invasive Approach the Nociception Level Index and Its Association With Pain and Anxieiy Perception Evaluated by Questionnaires, in Awake Women During Elective Cesarean Delivery Under Spinal Anesthesiaanxiety
Cesarean Delivery
Recruiting NCT07723261
Hellenic Evaluation of the Long-Term Safety and Efficacy of NalIriFOx as a 1st-line Therapy in Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
Recruiting NCT04615013
NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer
Cervical Esophagus Adenocarcinoma · Clinical Stage II Esophageal Adenocarcinoma AJCC v8 · Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8
Not yet recruiting NCT07726693
Apixaban to Prevent Decompensation of Early Liver Cirrhosis Trial
Liver Cirrhosis
Recruiting NCT07217899
Prophylactic Intravenous Calcium Gluconate to Decrease Blood Loss at Time of Cesarean Delivery in Pregnant Patients at High Risk for Uterine Atony
Blood Loss, Surgical · Blood Loss, Postoperative · Uterine Atony
Not yet recruiting NCT07118800
Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old
Locally Advanced Rectal Adenocarcinoma
Recruiting NCT05394714
A Phase I, Autologous ex Vivo Expanded and Activated NK Cell, Magicell-NK, Infusion for Colon Cancer Post Resection Study
Colon Cancer Stage I
Recruiting NCT06075745
Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
Liver Transplant
Recruiting NCT06291324
WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment
Pancreatic Cancer · Breast Cancer
Recruiting NCT06512454
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
Alpha1-Antitrypsin Deficiency
Not yet recruiting NCT07094893
Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type RAS and AREG/EREG High Status
Colorectal Cancer
Not yet recruiting NCT07623174
A Study of Fruquintinib in Adults With Metastatic Colorectal Cancer in Poland
Metastatic Colorectal Cancer
Not yet recruiting NCT07723534
Zolbetuximab With mFOLFOX6 or CAPOX in Claudin 18.2 Overexpressed Advanced or Metastatic Biliary Tract Cancers
Advanced Biliary Tract Cancer · Metastatic Biliary Tract Carcinoma
Recruiting NCT07549412
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Metastatic Colorectal Cancer
Recruiting NCT07606599
A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy Failure
Biliary Tract Cancer
Not yet recruiting NCT07720115
Phase 2 Trial Of S-531011 With RadScopal In Previously Treated Metastatic Colorectal Cancer
Phase II · S-531011 · RadScopal
Recruiting NCT07104604
Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Tislelizumab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement
Rectal Cancer
Recruiting NCT07409012
Development of a Patient-Centered Assessment Tool for Pain During Cesarean Delivery
Elective Cesarean Delivery
Recruiting NCT06445972
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
Gastroesophageal Junction · Gastroesophageal Adenocarcinoma · Esophageal Neoplasms
Recruiting NCT07582315
A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally Advanced or Metastatic Biliary Tract Cancer After Failure of Platinum-based Chemotherapy(PANKU-BTC01)
Biliary Tract Cancer
Recruiting NCT06280950
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
Liver Transplant
Not yet recruiting NCT07725874
Safety and Efficacy of Liposomal Amphotericin B for Patients With Invasive Mold Diseases in Liver Transplant Recipients
Invasive Mold Diseases
Not yet recruiting NCT07678567
Pomegranate Dietary Supplements in AUD and ALD
Alcohol Use Disorder · Alcohol-associated Liver Disease · Alcoholic Cirrhosis
Recruiting NCT07724223
Fruquintinib Plus Anti-EGFR Antibody for Third-Line Treatment of RAS Wild-Type mCRC
Metastatic Colorectal Cancer (CRC)
Enrolling by invitation NCT07725328
Pragmatic Mobile Health Trial to Promote Cancer Screening and Healthy Behaviors
Cancer Screening · Chronic Diseases in Older Adults · Early Cancer Detection
Recruiting NCT07724496
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
Helicobacter Pylori · Early Gastric Cancer
Recruiting NCT07291076
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
Hepatocellular Carcinoma (HCC)
Recruiting NCT07290985
AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas
Gastroesophageal Adenocarcinoma
Recruiting NCT07384234
SHR-1701 Combined With Chemotherapy for Gastric or Gastroesophageal Junction Adenocarcinoma With Peritoneal Metastasis
Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma
Recruiting NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Cancer · Colorectal Cancer · Solid Tumor
Recruiting NCT06588556
Improving Needs Among Older Adults
Critical Illness · Palliative Care · Older Adults
Recruiting NCT05028725
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma · Esophageal Squamous Dysplasia