Endocrinology

Recruiting NCT07716397☆ Save

Screening, Classification, and Outcome Prediction Ensemble Using Orbital MRI for Thyroid Eye Disease: The TED SCOPE National Multicenter Registry Study

— Observational China

Graves Ophthalmopathy · Graves Disease · Thyroid Associated Ophthalmopathies

Enrolling by invitation NCT07523672☆ Save

Effectiveness of a Care Model for Sarcopenic Obesity in Older Adults on Fat Mass, Muscle Mass, Muscle Strength, and Physical Performance

No phase Interventional Thailand

Sarcopenic Obesity

Recruiting NCT07708233☆ Save

Benfotiamine Versus Vitamin B1-6-12 for Diabetic Peripheral Neuropathy

Phase IV Interventional Thailand

Diabetic Peripheral Neuropathy (DPN)

Recruiting NCT02890342☆ Save

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

— Observational United States

Metabolic Disease · Propionic Acidemia · Organic Acidemia

Recruiting NCT07717554☆ Save

Effect of Virtual Yoga in Diabetic Gastroparesis Patients

No phase Interventional United States

Diabetic Gastroparesis

Recruiting NCT07717333☆ Save

Sarcopenia Indicators After Bariatric Surgery

— Observational Turkey (Türkiye)

Obesity · Sarcopenia · Bariatric Surgery

Enrolling by invitation NCT05503927☆ Save

A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy

— Observational United States

Pregnancy · Obesity · Overweight

Recruiting NCT06282952☆ Save

Health Outcomes in C-Section Infants With Fecal Microbiota Transplantation

No phase Interventional Finland

Fecal Microbiota Transplantation · Cesarean Section · Overweight and Obesity

Recruiting NCT07225816☆ Save

Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Phase I Interventional United States

Obesity

Not yet recruiting NCT07688434☆ Save

Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis

No phase Interventional Tunisia

End-stage Renal Disease (ESRD) · Chronic Hemodialysis · Metabolic Acidosis

Recruiting NCT07717424☆ Save

Assessment of Quality of Life and Psychological Factors Among Women Diagnosed With Gestational Diabetes Mellitus

— Observational India

Gestational Diabetes Mellitus (GDM)

Recruiting NCT07548996☆ Save

Open-Label Study of Dimethyl Fumarate in Adults With Type 1 Diabetes

Phase II / Phase III Interventional China

Type 1 Diabetes Mellitus

Recruiting NCT07717658☆ Save

Family-Based Weight Wellness Treatment Through Food is Medicine and Group Medical Visits in Pediatric and Adult Primary Care

No phase Interventional United States

Obesity & Overweight · Weight Management

Recruiting NCT07149142☆ Save

Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes

No phase Interventional Czechia

Type 1 Diabetes Mellitus

Recruiting NCT06672549☆ Save

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Phase III Interventional United States, Belgium +10

Obesity · Overweight

Recruiting NCT05188014☆ Save

Exercise and the Menstrual Cycle in Type 1 Diabetes

No phase Interventional Canada

Type 1 Diabetes

Recruiting NCT07351058☆ Save

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

Phase III Interventional United States, Argentina +17

Obesity or Overweight · Type 2 Diabetes Mellitus

Not yet recruiting NCT07668336☆ Save

A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

Phase III Interventional United States, Belgium +9

Diabetes Mellitus, Type 2

Not yet recruiting NCT07630233☆ Save

A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult Males

Phase I Interventional China

Type 2 Diabetes Mellitus (T2DM)

Not yet recruiting NCT07714759☆ Save

A Study Comparing Continuous Glucose Monitoring Augmented Nutritional Counseling and Standard of Care Treatment Strategies in a Three-Month Nutrition Intervention

No phase Interventional United States

Obesity & Overweight · Obese Adolescents · Metabolic Abnormalities

Not yet recruiting NCT07612475☆ Save

Universal Type 1 Diabetes Screening in Pediatrics

— Observational —

Type 1 Diabetes (T1D)

Recruiting NCT06745570☆ Save

Improving Sleep, Decision-Making, and Eating in Adolescents With Obesity

No phase Interventional United States

Adolescent Overweight · Adolescent Obesity · Sleep

Recruiting NCT07695675☆ Save

Community Dining, Walking, and Glucose in Older Adults

No phase Interventional China

Prediabetes

Not yet recruiting NCT07711899☆ Save

Plasma Taurine in Older Women With Obesity: Impact of Metabolic Phenotype and Combined Exercise

No phase Interventional —

Obesity (BMI>30) · Metabolically Healthy Obesity · Metabolically Unhealty Obese

Not yet recruiting NCT07711548☆ Save

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

No phase Interventional —

Obesity & Overweight · Weight Loss Maintenance

Recruiting NCT07675148☆ Save

Cooking Classes as a Family-based Intervention for Weight Reduction: Effects on Dietary Quality and Weight Management in Abu Dhabi (United Arab Emirates)

No phase Interventional United Arab Emirates

Obesity & Overweight · Culinary Medicine

Recruiting NCT07351045☆ Save

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

Phase III Interventional United States, Argentina +17

Obesity or Overweight

Recruiting NCT07013643☆ Save

A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity

Phase I Interventional United States

Healthy Participants

Recruiting NCT07270731☆ Save

A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 Diabetes

Phase I Interventional Germany

Healthy Volunteer · Type 2 Diabetes

Recruiting NCT07713030☆ Save

Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients

No phase Interventional Pakistan

PreDiabetes · Pre Diabetes · Prediabetic State

Recruiting NCT07231419☆ Save

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

Phase III Interventional United States

Diabetic Peripheral Neuropathic Pain

Recruiting NCT07712913☆ Save

Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia

Phase III Interventional Brazil

Diabetic Neuropathy · Neuropathic Pain · Neuralgia, Postherpetic

Recruiting NCT07588100☆ Save

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

Phase I Interventional United States

Diabetic Retinopathy

Recruiting NCT07593625☆ Save

Evaluating Glucose Control Using a Next-Generation AID Algorithm in Individuals With T1D

No phase Interventional New Zealand

Type 1 Diabetes · Type 1 Diabetes Mellitus · Diabetes (DM)

Enrolling by invitation NCT07057310☆ Save

Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women

Phase IV Interventional United States

Obesity · Menopause

Recruiting NCT06147973☆ Save

An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents

No phase Interventional United States

Overweight and Obesity

Recruiting NCT06617689☆ Save

Effect of Patient Education on Drinking Behaviour and Oral Hygiene in Patients Undergoing Bariatric Surgery

No phase Interventional Norway

Obesity · Bariatric Surgery Candidate

Not yet recruiting NCT07670572☆ Save

Think-Find-Solve Activities for Insulin Self-Management in Type 1 Diabetes

No phase Interventional Turkey (Türkiye)

Type 1 Diabetes · Children · Activity

Not yet recruiting NCT07715461☆ Save

Effect of macaúba Oil Combined With Green Exercises

No phase Interventional Brazil

Stress Mental · Dyslipidemia · Obesity & Overweight

Recruiting NCT07056699☆ Save

SGLT2i, Pioglitazone, and Ketone Production in T1D

Phase III Interventional United States

Type1diabetes

Not yet recruiting NCT07713836☆ Save

Nutrition Intervention Optimization to Better Utilize Resources and Support Health

No phase Interventional United States

Diabete Type 2 · Obesity & Overweight · Nutritional Intervention

Not yet recruiting NCT07710456☆ Save

Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders

— Observational —

Malnutrition · Sarcopenia · Obesity

Recruiting NCT07053319☆ Save

SGLT2i, Pioglitazone, and Ketone Production in T2D

Phase I Interventional United States

Type 2 Diabetes

Recruiting NCT07603739☆ Save

Eating Almonds Before a Meal to Control Blood Sugar

No phase Interventional United States

Glucose Control · Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) · Precision Medicine

Recruiting NCT05933707☆ Save

Small Extracellular Vesicles and Insulin Action

No phase Interventional United States

Obesity · Insulin Resistance · Metabolically Healthy Obesity

Not yet recruiting NCT07702630☆ Save

ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery

— Observational —

Gallstone Disease · Bariatric Surgery · Metabolic Surgery

Not yet recruiting NCT07710768☆ Save

A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

Phase I Interventional United States

Obesity · Overweight

Recruiting NCT05770570☆ Save

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Phase II Interventional United States

Overweight · Overweight and Obesity · Overweight or Obesity

Not yet recruiting NCT07710352☆ Save

Low Gas Pressure vs Standard Gas Pressure in Weight-Loss Surgery

No phase Interventional United States

Obesity & Overweight · Robotic Surgery · Pneumoperitoneum

Not yet recruiting NCT07711288☆ Save

A Two-part Study of Lembas Edge Evaluating Tolerability and Postprandial Glycemic Control

No phase Interventional Canada

Postprandial Glycemic Control · Prediabetic Overweight and Obese Adults

Recruiting NCT07253285☆ Save

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

Phase III Interventional United States, Australia +24

Overweight · Obesity

Recruiting NCT07617519☆ Save

Changing Outpatient Diabetes Care With Remote-Patient-Monitoring: A Real World Evidence Study With Pre-Post Comparison

— Observational Denmark

Diabetes · Diabetes Care · Diabetes Type 1

Recruiting NCT07425522☆ Save

A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)

Phase I Interventional United States

Diabetic Macular Edema

Recruiting NCT05960656☆ Save

SGLTi, Hepatic Glucose Production and Ketogenesis

Phase I Interventional United States

Type 2 Diabetes

Not yet recruiting NCT07710729☆ Save

A Research Study Looking Into How UBT251 Works With Birth Control Tablets and Emptying of the Stomach in Women With Excess Body Weight Not Able to Become Pregnant

Phase I Interventional Canada

Overweight · Obesity

Not yet recruiting NCT07709117☆ Save

A Pilot Study to Improve Diabetes Management Through Family-Based Health Care Navigation

No phase Interventional —

Diabetes

Recruiting NCT06688331☆ Save

Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody

Phase II Interventional Poland

Presymptomatic Diabetes Type 1 (Stage 1) · Diabetes Mellitus, Type I · Diabetes Mellitus, Type 1

Not yet recruiting NCT07710274☆ Save

Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I)

No phase Interventional Singapore

Metabolic Syndrome (MetS)

Recruiting NCT07215559☆ Save

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Phase II Interventional United States, Argentina +2

Obesity · Overweight · Diabetes Mellitus, Type 2

Not yet recruiting NCT07709910☆ Save

A Trial of Ribupatide Injection in Participants With Obesity and Knee Osteoarthritis

Phase III Interventional China

Participants With Obesity and Knee Osteoarthritis

Enrolling by invitation NCT07711925☆ Save

MRI Assessment of Body Composition in Bariatric Surgery

No phase Interventional Poland

Obesity (BMI>30)

Not yet recruiting NCT07712068☆ Save

Effects of Exercise Sequence and Meal Sequence on Weight Management Among Children and Adolescents With Overweight or Obesity: The STEP Trial

No phase Interventional China

Obesity & Overweight · Insulin Resistance · Inflamation

Recruiting NCT07711171☆ Save

Efficacy and Safety of Canagliflozin in the Treatment of Type 2 Diabetes With Mild Cognitive Impairment

Phase IV Interventional China

Type 2 Diabetes Mellitus · Cognitive Impairment

Recruiting NCT07053293☆ Save

SGLT2i, Hepatic Glucose Production, and SNS

Early Phase I Interventional United States

Type 2 Diabetes

Recruiting NCT07053306☆ Save

SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia

Phase I Interventional United States

Type 2 Diabetes

Recruiting NCT06368817☆ Save

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Phase II Interventional United States, Australia +1

Basal Ganglia Germinoma · Diabetes Insipidus · Germinoma

Recruiting NCT06988462☆ Save

Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

No phase Interventional United States

Prediabetes · Diabetes · High Cholesterol/Hyperlipidemia

Not yet recruiting NCT07707518☆ Save

Evaluating the Effectiveness of a Smart Screening and Tiered Management Tool for Diabetic Kidney Disease in Primary Care: A Cluster Randomized Trial

No phase Interventional China

Type 2 Diabetes Mellitus · Diabetic Kidney Disease

Recruiting NCT06528314☆ Save

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

Phase III Interventional United States, Argentina +17

NASH - Nonalcoholic Steatohepatitis · MASH - Metabolic Dysfunction-Associated Steatohepatitis

Recruiting NCT05965336☆ Save

Walking Function in Diabetic Peripheral Neuropathy

No phase Interventional United States

Diabetic Peripheral Neuropathy

Recruiting NCT05289310☆ Save

Low Oxygen Exposure and Weight Status

No phase Interventional United States

Obesity

Not yet recruiting NCT07706803☆ Save

Screening For Social Determinants Of Health In Routine Diabetes Care

No phase Interventional United States

Type 1 Diabetes

Not yet recruiting NCT07707830☆ Save

Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)

— Observational Uzbekistan

Hypothyroidism

Recruiting NCT07539415☆ Save

A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers

Phase I Interventional South Korea

Obesity & Overweight · Type 2 Diabetes

Not yet recruiting NCT07708610☆ Save

Preadmission GLP-1 Receptor Agonist Plus SGLT2 Inhibitor Use and Early Outcomes After Pneumonia Hospitalization in Adults With Type 2 Diabetes

— Observational Taiwan

Pneumonia · Type 2 Diabetes Mellitus (T2DM)

Recruiting NCT06790784☆ Save

Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

Phase III Interventional United States

Proliferative Diabetic Retinopathy (PDR)

Not yet recruiting NCT07706335☆ Save

Insulin Resistance and Its Association With no Reflow Phenomenon After Primary PCI in Type II Diabetic STEMI Patients.

— Observational —

STEMI · No-Reflow Phenomenon · Diabetic Patient

Recruiting NCT07654972☆ Save

A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Phase I Interventional United States, Singapore

Obesity · Overweight

Recruiting NCT06784375☆ Save

Individualized Diabetes Education Assisted by CGM (IDEA-CGM)

No phase Interventional United States

Type 2 Diabetes

Recruiting NCT07271186☆ Save

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

Phase II Interventional United States

Diabetic Kidney Disease (DKD)

Recruiting NCT05681468☆ Save

Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources

No phase Interventional Canada

PreDiabetes · Diabetes Mellitus, Type 2 · Overweight and Obesity

Recruiting NCT07665879☆ Save

A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity

Phase I Interventional Germany, Sweden

Overweight · Obesity

Recruiting NCT07228117☆ Save

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

No phase Interventional United States, Australia +1

Type 1 Diabetes Mellitus · Type 2 Diabetes Mellitus

Recruiting NCT07708064☆ Save

Testing Just-in-Time Adaptive Interventions (JITAIs) to Prevent Goal Disengagement in Response to Weight Regain

No phase Interventional United States

Overweight or Obesity

Not yet recruiting NCT07704229☆ Save

Investigating Metabolic, Brain, and Cognitive Alterations Through Bariatric Surgery

— Observational Canada

Obesity, Morbid

Not yet recruiting NCT07704606☆ Save

Metabolites in Blood and Breath in Metabolic Conditions

— Observational —

Inborn Errors of Metabolism · Epilepsy (Treatment Refractory)

Recruiting NCT06924177☆ Save

UTSW NORC Pilot Spinal Cord Injury Dietary Program

No phase Interventional United States

Obesity and Obesity-related Medical Conditions · Spinal Cord Injury, Chronic

Recruiting NCT07496177☆ Save

A Mechanistic Study on the Effect of HTD1801 Versus Placebo on Kidney Function in Patients With Type 2 Diabetes and Chronic Kidney Disease.

Phase II Interventional China

T2DM · CKD

Recruiting NCT06934642☆ Save

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

Early Phase I Interventional United States

MASLD · Obesity

Recruiting NCT06575738☆ Save

Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

Phase I Interventional United States

Obesity · Adolescent Obesity · Body-Weight Trajectory

Not yet recruiting NCT07704944☆ Save

Safety and Dose-Response of Bletilla Formosana in Prediabetic Subjects

Phase I / Phase II Interventional Taiwan

Prediabetes

Not yet recruiting NCT07229781☆ Save

Mediterranean Diet and Blood Sugar Study

No phase Interventional —

Prediabetes

Not yet recruiting NCT07705607☆ Save

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)

Phase III Interventional —

Diabetic Retinopathy · Macular Edema

Recruiting NCT07698145☆ Save

Changes in Body Composition Including Muscle With Anti-Obesity Medications, Both With and Without Exercise

No phase Interventional United States

Obesity & Overweight

Not yet recruiting NCT07705958☆ Save

OTAGO Exercises in Diabetes Mellitus Examining Its Effectiveness

No phase Interventional —

Diabetes Mellitus · Balance

Recruiting NCT05799846☆ Save

Cognitive Strategies for Weight Loss

No phase Interventional United States

Obesity

Recruiting NCT07667504☆ Save

Dietary Approaches for the Management of Overweight and Obesity in Type 1 Diabetes

No phase Interventional Spain

Type 1 Diabetes (T1D) · Obesity & Overweight

Not yet recruiting NCT07705555☆ Save

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)

Phase III Interventional —

Diabetic Retinopathy · Macular Edema

Not yet recruiting NCT07706088☆ Save

Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy

Phase IV Interventional —

Neuropathy, Small Fiber · Diabete Mellitus

Not yet recruiting NCT07705750☆ Save

Effects of Adapted Taekwondo Versus Conventional Training on Anthropometric Variables and Physical Function in Older Women With Abdominal Obesity

No phase Interventional —

Obesity & Overweight · Older Women