Not yet recruiting NCT07443176
FCI-Glioblastoma Study
Glioblastom WHO Grade 4
CNS tumors
876 trials in this section
Recruiting NCT04540107
Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
Recurrent World Health Organization (WHO) Grade II Glioma · Recurrent WHO Grade III Glioma · WHO Grade II Glioma
Recruiting NCT07297212
A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma
Recurrent Glioblastoma
Recruiting NCT07017816
A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.
CNS Malignancies · Medulloblastoma Recurrent · ATRT Recurrent
Recruiting NCT05555550
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG
Glioma · Low-grade Glioma · Low Grade Glioma of Brain
Recruiting NCT06012695
NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma
Malignant Neoplasm · Malignant Neoplasm of Brain
Recruiting NCT06039709
Sonodynamic Therapy in Patients With Recurrent GBM
Recurrent Glioblastoma · Glioblastoma Multiforme · GBM
Recruiting NCT04222062
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
Brain Tumor - Metastatic
Recruiting NCT04696029
DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma
Medulloblastoma
Recruiting NCT06667726
An Investigational Scan (18F-DOPA PET/CT) for Improving the Clinical Management of Brain Tumors
Malignant Brain Neoplasm
Recruiting NCT03206060
Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
Pheochromocytoma · Paraganglioma · Neuroendocrine Tumors
Enrolling by invitation NCT03170141
Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
Glioblastoma Multiforme of Brain · Brain Cancer
Not yet recruiting NCT07546669
Efficacy of Zoster Vaccination in Glioblastoma Patients
Glioblastoma (GBM)
Recruiting NCT07547163
Patient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Compared
Glioma · Glioma of Brain · Low Grade Glioma of Brain
Recruiting NCT03383978
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
Glioblastoma
Recruiting NCT04322734
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Autism Spectrum Disorder · Mitochondrial Pathology · Epilepsy
Recruiting NCT04692324
Cerebrospinal Fluid Biomarkers for Brain Tumors
Central Nervous System Neoplasm
Recruiting NCT05030298
Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial
Malignant Glioma
Recruiting NCT04082520
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy
Grade 1 Meningioma · Grade 2 Meningioma · Grade 3 Meningioma
Enrolling by invitation NCT07542158
Ultralow Dose PET Imaging of 18F-FDOPA
Heathy Volunteer · Parkinsonian Syndromes · Neuroendocrine (NE) Tumors
Recruiting NCT05917145
ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma
Glioblastoma
Recruiting NCT03684109
Non-invasive Glioma Characterization Through Molecular Imaging
Glioma · Brain Tumor · Primary Brain Tumor
Recruiting NCT07538128
Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma
Recurrent Glioblastoma
Recruiting NCT03728673
A Study Utilizing Escitalopram in Glioma Patients
Glioma of Brain · Glioma
Recruiting NCT07224503
C-SMART vs BE Well for Patients With Brain Tumors
Brain Tumor
Recruiting NCT06466031
Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO]
Glioblastoma Multiforme
Recruiting NCT03122197
Study of Letrozole in Recurrent Gliomas
Brain Tumor
Recruiting NCT06610682
A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma
BRAF V600E Mutation
Recruiting NCT07100730
Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma
Neoplastic Disease · Glioblastoma · Glioblastoma (GBM)
Recruiting NCT05580562
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
H3 K27M · Glioma
Not yet recruiting NCT07532031
APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade Gliomas
High-Grade Glioma · Glioblastoma · Brain Tumor Adult
Recruiting NCT07530536
rTMS for Postoperative Brain Tumor Patients
Brain Tumors · Transcranial Magnetic Stimulation · Motor Deficit
Recruiting NCT05057702
Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma
Medulloblastoma · Medulloblastoma, Childhood · Medulloblastoma Recurrent
Recruiting NCT03286335
Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
Brain Tumor
Recruiting NCT06126744
Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252
Recurrent High Grade Glioma
Recruiting NCT06512311
Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening
Glioblastoma
Recruiting NCT07185880
A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients
Glioblastoma (GBM)
Recruiting NCT06419946
Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma
Glioblastoma, IDH-wildtype · MGMT-Methylated Glioblastoma
Recruiting NCT07242963
Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study
Medulloblastoma Recurrent · Medulloblastoma, Childhood, Recurrent · Medulloblastoma, SHH-activated and TP53 Mutant
Not yet recruiting NCT07521657
Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma
Neurofibromatosis 1 (NF1)
Recruiting NCT06599879
Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention
Brain Tumor, Pediatric
Recruiting NCT06329570
Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)
Glioblastoma Multiforme · Glioblastoma · Glioma
Recruiting NCT06496971
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
Glioblastoma Multiforme · Glioblastoma · Glioblastoma Multiforme, Adult
Not yet recruiting NCT07520370
Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor
Brain Tumor · Stroke · Ulinastatin
Recruiting NCT07134842
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
Glioblastoma · Gliosarcoma, Adult · Glioblastoma - Category
Enrolling by invitation NCT07520214
Clinical Study on the Safety and Immunogenicity of Specific Cancer Vaccines in Preventing Recurrence of Glioblastoma
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype · Glioblastom WHO Grade 4
Recruiting NCT07301268
GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma
Glioblastoma, IDH-Wildtype · Progressive Astrocytoma, IDH-Mutant, Grade 4 · Progressive Glioblastoma
Not yet recruiting NCT07516275
Prospective Cohort Study of Pheochromocytoma/Paraganglioma
Pheochromocytoma · Paraganglioma · Hemodynamic Instability
Not yet recruiting NCT07515924
Oral Gallium Maltolate for Recurrent Glioblastoma
Glioblastoma
Recruiting NCT07488754
Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4)
Glioblastoma · High-Grade Glioma (WHO III-IV) · Glioblastoma (GBM)
Recruiting NCT07511725
Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk Glioblastoma
Glioblastoma (GBM)
Recruiting NCT05789394
Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy
Recurrent Glioblastoma, IDH-Wildtype · Recurrent Astrocytoma, IDH-Mutant, Grade 4 · Astrocytoma, Grade IV
Recruiting NCT07506239
Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma
Low-grade Glioma · Recurrent Low Grade Glioma · Low Grade Glioma of Brain
Recruiting NCT05819008
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
Traumatic Brain Injury · Stroke · Multiple Sclerosis
Recruiting NCT07501156
H3K27M-specific Immune Effector Cells Targeting DMG/DIPG
Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma
Recruiting NCT07501559
A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of JL15003 Injection in Patients With Recurrent Glioblastoma (rGBM)
Recurrent Glioblastoma Multiforme(GBM)
Not yet recruiting NCT07431216
A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First Progression
Glioblastoma (GBM)
Recruiting NCT03596086
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
Glioblastoma Multiforme · Astrocytoma, Grade III
Recruiting NCT04559230
Sacituzumab Govitecan in Recurrent Glioblastoma
Recurrent Glioblastoma
Not yet recruiting NCT07499479
Picture Naming Decoding From Intraoperative Recordings
Brain Tumor Adult
Not yet recruiting NCT07496073
A Phase I, Single-arm, Open-label Clinical Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of CHT101 Cell Infusion in Adult Subjects With Recurrent or Progressive Malignant Primary Brain Tumors（CROWN）
Brain (Nervous System) Cancers
Not yet recruiting NCT06630338
Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements
Brain Tumor · Recurrent Brain Tumor · Brain Neoplasm
Not yet recruiting NCT07492836
Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma
Glioblastoma (GBM)
Recruiting NCT05212272
MRI in High-Grade Glioma Patients Undergoing Chemoradiation
High Grade Glioma
Enrolling by invitation NCT07126990
Clinical Study of a Novel Oncolytic Virus Ad-TD-nsIL12 in the Treatment of Primary High-grade Glioma
Glioma
Not yet recruiting NCT07089758
A Study for Cerebral Open Flow Microperfusion
Glioma · Glioblastoma
Enrolling by invitation NCT06763965
Evaluating the Safety and Efficacy of BioTTT001 in Patients With Recurrent/Progressive High-grade Glioma.
Recurrent High-grade Glioma
Recruiting NCT06165653
Guided Meditation During Radiation Therapy for Brain Tumors
Brain Neoplasms
Recruiting NCT06352710
Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment
Disc Disease · Instabilities Lumbar · Brain Tumor
Recruiting NCT06229483
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Brain Tumor · Bleeding
Recruiting NCT04033497
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
Brain Tumor
Recruiting NCT04655404
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
High Grade Glioma · Diffuse Intrinsic Pontine Glioma
Recruiting NCT04943848
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Diffuse Intrinsic Pontine Glioma · Diffuse Midline Glioma, H3 K27M-Mutant
Recruiting NCT07476794
Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma
Glioblastoma
Not yet recruiting NCT07472387
Impact of Androgen Signaling on the Composition of the Immune Microenvironment in Glioblastomas
Glioblastoma (GBM)
Recruiting NCT06186401
Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells
EGFR Gene Mutation · Glioblastoma · MGMT-Unmethylated Glioblastoma
Not yet recruiting NCT07470606
Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain
Brain Tumor
Recruiting NCT05940493
Abemaciclib in Newly Diagnosed Meningioma Patients
Meningioma
Not yet recruiting NCT07471100
Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS)
Brain Tumor Adult · Glioma · Glioma, High Grade
Not yet recruiting NCT07469735
Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma
Glioma · Diffuse Glioma · Recurrent Gliomas
Not yet recruiting NCT07468370
Real Time Craniotomy Planning Using Mixed Reality
Neurosurgery · Surgical Planning · Brain Tumor Adult
Recruiting NCT06504381
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
High Grade Glioma · MGMT-Unmethylated Glioblastoma · MGMT-Methylated Glioblastoma
Recruiting NCT03067467
Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)
Brain Tumor Adult
Recruiting NCT07461948
Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients
Glioblastoma
Recruiting NCT07460037
Chinese-Specific Speech Imagery Coding Using High-Density ECoG
Aphasia · Dysarthria · ALS
Recruiting NCT07063693
ABY-029 Glioma Trial
Intracranial Tumor
Recruiting NCT06104930
Plasma Extracellular Vesicles in Meningioma Patients
Meningioma
Recruiting NCT07459101
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4
Glioblastoma (GBM) · Astrocytoma, Grade IV
Recruiting NCT05859659
Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)
Brain (Nervous System) Cancers · Glioma · Brain Tumor
Not yet recruiting NCT07457307
Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac
High-grade Glioma
Recruiting NCT07268053
A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases
Glioblastoma (GBM) · Brain Metastasases
Recruiting NCT07446842
Construction of AI Model for Precision Imaging Diagnosis of Cranial Diseases
Cranial Diseases (e.g., Brain Tumors, Stroke, Neurodegenerative Disorders)
Not yet recruiting NCT07455045
A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)
High Grade Glioma (III or IV) · Diffuse Midline Glioma (DMG) · Glioblastoma (GBM)
Recruiting NCT05559853
Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment
Brain Metastases · Brain Metastases, Adult · Metastatic Brain Tumor
Recruiting NCT04373720
MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas
Glioma
Recruiting NCT06917885
CUE-102 in Recurrent Glioblastoma
Recurrent Glioblastoma · Glioblastoma · Glioma, Malignant
Recruiting NCT04771806
Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma
Malignant Glioma
Recruiting NCT06546631
Investigating Mechanistic Predictors of Interpatient Variability and Temozolomide (TMZ) Induced Haematological Toxicity for Glioma Patients
Glioma
Recruiting NCT07186556
Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention
Cancer · Fatigue · Brain Tumor Adult
Recruiting NCT05463848
Surgical Pembro +/- Olaparib w TMZ for rGBM
Glioblastoma · Recurrent Glioblastoma