Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment

Обзор

This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the maintenance effects of different training frequencies after the initial intervention. A quasi-experimental study will be conducted in three communities in Shenyang, Liaoning Province, China. All participants will receive a 12-week adaptive CCT program. Participants will be assigned to either a high-frequency maintenance training group or a training discontinuation group. Cognitive assessments will be performed at baseline, immediately after the intervention, and during follow-up. The primary outcome is global cognitive function, while secondary outcomes include memory, attention, executive function, language, visuospatial ability, and activities of daily living. The findings of this study are expected to provide evidence for optimizing computerized cognitive training programs and long-term management strategies for older adults with MCI in community settings.

Подробное описание

With the rapid aging of the global population, mild cognitive impairment (MCI) has become a critical stage for dementia prevention and early intervention. Cognitive training is recognized as one of the most effective non-pharmacological interventions for individuals with MCI. Among various approaches, adaptive computerized cognitive training (CCT) can dynamically adjust task difficulty according to an individual's performance, thereby improving training personalization, engagement, and adherence. However, evidence regarding the optimal maintenance training frequency and the long-term sustainability of cognitive benefits remains limited.

This study adopts a quasi-experimental design and will recruit community-dwelling adults aged 60 years and older with MCI from three communities in Shenyang, Liaoning Province, China. All participants will complete a 12-week adaptive computerized cognitive training program using the Heling Brain Planet WeChat mini-program, with training sessions lasting 30 minutes, three times per week. After the initial intervention, participants will be assigned to either a high-frequency maintenance training group, which will continue training three times per week, or a training discontinuation group, which will receive routine community health management only. Follow-up cognitive assessments will be conducted after the intervention and during the follow-up period.

The primary outcome will be global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes will include memory (Auditory Verbal Learning Test, AVLT), attention (Trail Making Test Part A, TMT-A), executive function (Stroop Color-Word Test), language (Boston Naming Test, BNT), visuospatial ability (Clock Drawing Test, CDT), and activities of daily living (ADL). The effects of different maintenance training frequencies on cognitive improvement and the persistence of intervention benefits will be compared.

This study is expected to evaluate the effectiveness of adaptive computerized cognitive training for improving cognitive function in community-dwelling older adults with MCI and to determine whether continued maintenance training can prolong cognitive benefits. The findings will provide evidence for optimizing community-based digital cognitive training programs and developing sustainable intervention strategies for the long-term management of older adults with MCI.

Вмешательства

• Поведенческое Adaptive Computerized Cognitive Training
  Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. D
• Поведенческое Adaptive Computerized Cognitive Training
  Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. D

Первичные конечные точки

• Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA) [Срок оценки: Baseline, Month 3, Month 4, and Month 6]

Вторичные конечные точки (6)

• Change in cognitive function assessed by the Mini-Mental State Examination (MMSE) [Срок оценки: Baseline, Month 3, Month 4, and Month 6]
• Change in language function assessed by the Boston Naming Test (BNT) [Срок оценки: Baseline, Month 3, Month 4, and Month 6]
• Change in attention assessed by the Trail Making Test Part A (TMT-A) [Срок оценки: Baseline, Month 3, Month 4, and Month 6]
• Change in executive function assessed by the Stroop Color-Word Test [Срок оценки: Baseline, Month 3, Month 4, and Month 6]
• Change in visuospatial function assessed by the Clock Drawing Test (CDT) [Срок оценки: Baseline, Month 3, Month 4, and Month 6]
• Change in activities of daily living assessed by the Activities of Daily Living (ADL) scale [Срок оценки: Baseline, Month 3, Month 4, and Month 6]

Критерии участия

Критерии включения

• Age >= 60 years;
• Planning to reside in the community for at least 12 months, with no intention to move into a nursing home;
• No clinical diagnosis of dementia;
• Meeting the diagnostic criteria for mild cognitive impairment (MCI) as defined in the Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Related Mild Cognitive Impairment (2021), The cut-off scores for the Beijing version of the Montreal Cognitive Assessment (MoCA) were adjusted for educational level: <=13 for junior high school or below, <=19 for high school, and <=24 for college education or above. Mini-Mental State Examination (MMSE) score >= 24; Activities of Daily Living (ADL) score <23.
• Able to use a mobile application (mini program) to perform cognitive training.

Критерии исключения

• Individuals unable to complete the questionnaires due to hearing or visual impairments;
• Those with other organic diseases of the central nervous system, such as brain tumors, epilepsy, or Parkinson's disease;
• Those diagnosed with severe mental disorders, such as schizophrenia, depression, or anxiety disorders.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Ren'ai Changwan Community Elderly Care Service Station, Dadong — Шэньян

Идентификаторы

NCT: NCT07753382 · China Medical University

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗