Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA

Официальное название

Inspiratory Muscle Training as an Adjunct to Standard Care: Effects on Cardiopulmonary Endurance and Functional Mobility in Knee Osteoarthritis

Обзор

The purpose of the study is to investigate whether adding Inspiratory Muscle Training (IMT) to the usual treatment of patients with knee osteoarthritis improves their cardiopulmonary endurance and functional mobility more than standard care alone.

Подробное описание

Knee osteoarthritis (KOA) is a common degenerative joint disorder associated with pain, stiffness, reduced mobility, and decreased physical activity. Reduced activity levels often result in impaired cardiopulmonary fitness and decreased aerobic capacity. Previous evidence suggests that individuals with severe KOA exhibit diminished inspiratory muscle strength and lower exercise tolerance. Inspiratory Muscle Training (IMT) strengthens respiratory muscles and improves ventilatory efficiency. IMT is a technique in which a person breathes in against resistance using a special device such as POWERbreathe to make the breathing muscles stronger. Since conventional rehabilitation primarily focuses on pain reduction and lower limb strengthening, incorporating IMT may provide additional benefits without imposing extra stress on the knee joint. This study aims to compare conventional KOA treatment combined with IMT against conventional treatment combined with sham IMT over a six-week intervention period.

Вмешательства

• Устройство POWERBREATH
  The POWERBREATH devices utilize calibrated resistance valves to force your breathing muscles to work harder, which naturally builds their power, stamina, and efficiency. IMT through POWERbreathe * 30 quick breaths two times a day at an adjustable resistance (equivalent to∼50% of (baseline) MIP). * Increased up to 35 breaths as per patient's tolerance.
• Устройство SHAM IMT
  * 60 slow breaths once daily at a load setting of 0 (corresponding to∼15% (baseline) MIP). * Training load adjustment was prevented using sticky tape applied to the device's load adjuster.

Первичные конечные точки

• Six-Minute Walk Test Assessment of cardiopulmonary endurance and aerobic capacity. Time Frame: Baseline, Week 3, Week 6 Six-Minute Walk Test (6MWT) Assessment of cardiopulmonary endurance and aerobic capacity. Time Frame: Baseline, Week 3, Wee [Срок оценки: Baseline, Week 3, Week 6]
• . Timed Up and Go Test (TUG) [Срок оценки: Time Frame: Baseline, Week 3, Week 6]

Вторичные конечные точки (2)

• Visual Analogue Scale (VAS) [Срок оценки: : Baseline, Week 3, Week 6]
• Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) [Срок оценки: Baseline, Week 3, Week 6]

Критерии участия

Критерии включения

• Age 40-65 years
• Male and Female participants
• Bilateral Knee Osteoarthritis
• Diagnosed according to American College of Rheumatology criteria
• Kellgren and Lawrence Grade II-III
• Able to walk independently
• Willing to provide informed consent

Критерии исключения

• Participation in structured physical activity programs
• Intra-articular corticosteroid injection within last 3 months
• Hyaluronic acid injection within last 6 months
• Lower limb trauma or surgery history
• Planned surgery during study period
• Severe cardiovascular disease
• Severe pulmonary disease
• Neurological disorders
• Psychological disorders

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Пакистан · 1 центр

• IIMCT Railway general hospital — Rawalpindi

Идентификаторы

NCT: NCT07738627 · Shagufta

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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