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Набор скоро начнётся NCT07727772

Vascular Aging and Acute Kidney Injury After Cardiac Surgery

— Наблюдательное Acute Kidney Injury Cardiac Surgery Postoperative Complications Vascular Aging

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Multidimensional Vascular Aging Assessment.
Кому может быть актуально
Состояния в реестре: Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging. Базовые параметры: от 18 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
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Официальное название

Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery

Обзор

This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.

Подробное описание

Acute kidney injury is a common postoperative complication after cardiac surgery and is associated with adverse short-term and long-term outcomes. Vascular aging may reflect systemic vascular dysfunction, impaired vascular compliance, endothelial dysfunction, and reduced renal perfusion reserve, which may increase susceptibility to postoperative acute kidney injury.

This prospective observational cohort study will include adult patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Perioperative vascular aging-related indicators will be collected according to the study protocol. These indicators may include noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. Postoperative renal function will be monitored after surgery, and acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria.

The primary objective is to investigate the association between multidimensional vascular aging markers and the occurrence and severity of postoperative acute kidney injury. Secondary analyses may evaluate the relationships between vascular aging burden and postoperative clinical outcomes, including intensive care unit stay, hospital stay, and other postoperative complications when available. This is an observational study, and no treatment, surgical procedure, or perioperative management strategy will be assigned by the study protocol.

Вмешательства

  • Другое Multidimensional Vascular Aging Assessment
    Perioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.

Первичные конечные точки

  • Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery [Срок оценки: From the date of surgery to postoperative day 7]
Вторичные конечные точки (1)
  • Severity of Postoperative Acute Kidney Injury [Срок оценки: From the date of surgery to postoperative day 7]

Критерии участия

Критерии включения

  • Adult patients aged 18 years or older.
  • Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
  • Patients who are able to provide written informed consent.
  • Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.

Критерии исключения

  • Patients younger than 18 years.
  • Patients with preoperative end-stage renal disease or maintenance dialysis.
  • Patients who are unable to complete the study-specified vascular aging assessment.
  • Patients who decline participation or withdraw informed consent.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Китай · 1 центр
  • Nanjing First Hospital, Nanjing Medical University — Нанкин

Идентификаторы

NCT: NCT07727772 · KY20260625-09

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗