Effects of Tool Handling on Language Processing

Официальное название

Analysis of the Effect of a Tool-Handling Intervention in a Specific Context on the Linguistic Processing of Healthy Young Adults

Обзор

This randomized controlled trial aims to investigate the effects of a context-specific tool-handling intervention on linguistic processing in healthy young adults. Participants will be allocated into three groups: a dexterous tool-use training group, a dexterous manual training group without tools, and a Control group. The dexterous tool-use training group will perform a task-oriented activity involving the use of tweezers to place colored beads into a mandala within a specific functional context. The intervention requires sequential motor planning, force control, precision, and goal-directed tool use. The dexterous manual training group without tools will perform a similar bead-placement activity without tool use, involving direct hand manipulation and lower task complexity. Both intervention groups will participate in synchronous online sessions via Google Meet for 20 minutes per day, five times per week, over a two-week period. The Control group will not receive any structured intervention and will instead be instructed to perform one activity of daily living using the non-dominant upper limb once per day during the two-week period. Linguistic processing will be assessed through a sentence judgment task involving sentences with and without semantic violations, in which participants will classify the sentences as correct or incorrect while electroencephalographic activity (EEG) is recorded. Additionally, sleep quality and manual dexterity will also be evaluated. The findings of this study may contribute to understanding the relationship between tool-related motor training and linguistic processing, particularly the interaction between motor and language systems in healthy young adults. Additionally, the study may provide evidence regarding neurophysiological changes associated with context-specific motor interventions.

Вмешательства

• Поведенческое Dexterous tool-use training
  The intervention will be supervised by a researcher through assynchronous way. Participants will perform a task-oriented activity involving the use of tweezers to place colored beads into a mandala within a functional and goal-directed context.
• Поведенческое Dexterous manual training group without tools (Online)
  The intervention will be supervised by a researcher through assynchronous way. Participants will perform a bead-placement activity directly with their hands, without the use of tools.
• Поведенческое Control
  Participants allocated to the control group will not receive structured training. They will be instructed to perform one activity of daily living using the non-dominant upper limb once per day during the two-week study period.

Первичные конечные точки

• Assessment of Synthatic Processing Performance - Reaction time [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• Assessment of Synthatic Processing Performance - Accuracy [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]

Вторичные конечные точки (8)

• N200 Event-Related Potential Mean Amplitude [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• P300 Event-Related Potential Mean Amplitude [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• N200 Event-Related Potential Peak Latency [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• P300 Event-Related Potential Peak latency [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• Assessment of Syntactic Production - Hierarchical Embedding in Spontaneous Discourse [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• Assessment of Syntactic Production - Clauses per Sentence in Spontaneous Discourse [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• Assessment of Syntactic Production - Left-Branching Load (Frazier Index) in Spontaneous Discourse [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]
• Manual dexterity [Срок оценки: Change from PRE assessment (up to 1 week before intervention) to POST assessment (up to 1 week after intervention completion)]

Критерии участия

Критерии включения

• Healthy young adults aged between 19 and 24 years;
• Right-handed individuals.

Критерии исключения

• Previous diagnosis of neurological and/or psychiatric disorders;
• History of traumatic brain injury;
• Use of psychoactive substances or medications that may affect cognitive functioning;
• Pregnancy or suspected pregnancy.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Лечение

Центры проведения

Бразилия · 1 центр

• UFCSPA — Porto Alegre

Идентификаторы

NCT: NCT07718698 · TOOLANG

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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