Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)

Обзор

Speech and communication disorders often result in aberrant control of the timing of speech production, such as making improper stops at places where they should not be. During normal speech, the ability to stop when necessary is important for maintaining turn-taking in a smooth conversation. Existing studies have largely investigated neural circuits that support the preparation and generation of speech sounds. It is believed that activity in the prefrontal and premotor cortical areas facilitates high-level speech control and activity in the ventral part of the sensorimotor cortex controls the articulator (e.g. lip, jaw, tongue) movements. However, little is known about the neural mechanism controlling a sudden and voluntary stop of speech. Traditional view attributes this to a disengagement of motor signals while recent evidence suggested there may be an inhibitory control mechanism. This gap in knowledge limits our understanding of disorders like stuttering and aphasia, where deficits in speech timing control are among the common symptoms. The overall goal of this study is to determine how the brain controls the stopping of ongoing speech production to deepen our understanding of speech and communication in normal and impaired conditions.

Подробное описание

Intracranial electroencephalography (iEEG) is a state-of-the-art technique with fine spatial and temporal resolutions that are well suited for studying the neural dynamics of speech. This study proposes to assess speech production in patients who are undergoing iEEG recording to carry out clinical procedures for indications related to their medical condition. The research study team will investigate neural signals correlated with speech stopping using speech production and stopping tasks with visual cues. The research study team will compare effects on neural activity within each individual subject and identify common patterns of activity across subjects. The aims of this study seek to determine the role of the premotor network for stopping during naturalistic usage. This study will provide basic knowledge for the precise control of speech stopping and the control of speech timing in general, bridging the current speech production studies to real-world communication conditions, and help inspire new theories of speech motor control.

Вмешательства

• Поведенческое Speech Production Tasks
  View visual cues and undergo speech production.

Первичные конечные точки

• Mean Change in Neural Activity [Срок оценки: During inpatient hospitalization, up to 14 days after surgical electrode implantation]

Критерии участия

Критерии включения

• Undergoing iEEG placement in regions of interest (e.g., in the frontal or temporal cortex) for clinically necessary localization of epileptic foci or language mapping
• Fluent English speakers
• Within the normal range for cognitive, speech-language, and hearing capacity
• Normal or corrected-to-normal visual acuity

Критерии исключения

• Individuals with intellectual disability
• Lack of fluent English comprehension/production
• Inadequate speech ability for the research tasks.
• History of autism or ADHD

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• UPMC Children's Hospital of Pittsburgh — Pittsburgh

Идентификаторы

NCT: NCT07713706 · STUDY25040153 · R00DC020235

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗