MRI Assessment of Body Composition in Bariatric Surgery

Официальное название

Assessment of Adipose Tissue and Skeletal Muscle Distribution by Magnetic Resonance Imaging in Patients Before and After Surgical Treatment of Obesity

Обзор

The goal of this observational study is to evaluate changes in adipose tissue and skeletal muscle distribution using magnetic resonance imaging (MRI) in adults with obesity undergoing bariatric surgery. The study also aims to investigate the relationship between MRI-derived body composition parameters and metabolic outcomes following surgical treatment of obesity. The main questions it aims to answer are: How does bariatric surgery affect the distribution of visceral, subcutaneous, hepatic, perirenal adipose tissue and skeletal muscle over 12 months? Are changes in MRI-derived body composition associated with improvements in metabolic parameters after bariatric surgery? Participants will: undergo MRI examinations before bariatric surgery and at 1, 6, and 12 months after surgery; undergo routine clinical and metabolic assessments during standard postoperative follow-up; have MRI-derived body composition measurements correlated with metabolic outcomes over the 12-month follow-up period.

Подробное описание

Obesity is a chronic metabolic disease associated with increased morbidity and mortality. Beyond body mass index (BMI), the distribution of adipose tissue, particularly visceral adipose tissue, plays a critical role in the development of insulin resistance, type 2 diabetes, cardiovascular disease, and metabolic dysfunction-associated steatotic liver disease. In addition, skeletal muscle quantity and quality are increasingly recognized as important determinants of metabolic health and postoperative recovery.

Magnetic resonance imaging (MRI) is considered the reference standard for non-invasive assessment of body composition, allowing accurate quantification of visceral and subcutaneous adipose tissue, skeletal muscle volume, intramuscular fat infiltration, and ectopic fat depots without exposure to ionizing radiation. Although bariatric surgery has been shown to induce substantial weight loss and improve metabolic outcomes, the temporal changes in regional adipose tissue distribution and skeletal muscle composition remain incompletely understood.

This prospective observational study aims to characterize longitudinal changes in body composition using MRI in patients undergoing bariatric surgery. MRI examinations will be performed before surgery and during postoperative follow-up to evaluate changes in visceral, subcutaneous, hepatic, perirenal, and intramuscular fat, as well as skeletal muscle volume. These imaging findings will be correlated with routinely collected clinical and metabolic parameters to improve understanding of body composition remodeling after bariatric surgery.

The results of this study may contribute to identifying imaging biomarkers associated with metabolic improvement after bariatric surgery and support the development of more personalized strategies for postoperative monitoring and patient management.

Вмешательства

• Диагностический тест MRI
  Magnetic resonance imaging (MRI) will be used to assess body composition before bariatric surgery and at 1, 3, and 12 months after surgery. MRI examinations will quantify visceral and subcutaneous adipose tissue, skeletal muscle volume, intramuscular fat, hepatic fat, and perirenal fat. Imaging findings will be analyzed longitudinally and correlated with routine clinical and metabolic parameters to evaluate changes in body composition following bariatric surgery.

Первичные конечные точки

• Change in abdominal adipose tissue distribution assessed by magnetic resonance imaging (MRI) [Срок оценки: Baseline and 3 and 12 months after bariatric surgery]

Вторичные конечные точки (5)

• Change in skeletal muscle volume [Срок оценки: Baseline, 3 months, and 12 months after bariatric surgery]
• Change in hepatic fat content [Срок оценки: Baseline, 3 months, and 12 months after bariatric surgery]
• Change in glycated hemoglobin (HbA1c) [Срок оценки: Baseline, 3 months, and 12 months after bariatric surgery.]
• Change in serum triglyceride concentration [Срок оценки: Baseline, 3 months, and 12 months after bariatric surgery.]
• Change in lipoprotein(a) concentration [Срок оценки: Baseline, 3 months, and 12 months after bariatric surgery.]

Критерии участия

Критерии включения

• Age 18 years or older
• BMI >= 30 kg/m2
• qualified to undergo bariatric surgery
• Ability to provide written informed consent
• Willingness to undergo magnetic resonance imaging before surgery and 3, and 12 months after surgery

Критерии исключения

• Previous bariatric surgery
• Presence of ferromagnetic implants or other contraindications to magnetic resonance imaging
• Previous plastic or surgical procedures affecting the body region assessed by MRI, except cholecystectomy, appendectomy, or inguinal hernia repair
• Chronic kidney disease stage 4 or higher
• Pregnancy
• Claustrophobia preventing MRI examination
• Inability or unwillingness to provide informed consent

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Диагностика

Центры проведения

Польша · 1 центр

• University of Warmia and Mazury — Olsztyn

Публикации

• Bai J, Wang S, Pan H, Shi Z, Zhao M, Yue X, Yang K, Zhang X, Wang W, Liu C, Zhang T. Correlation analysis of dynamic changes of abdominal fat during rapid weight loss after bariatric surgery: A prospective magnetic resonance imaging study. Eur J Radiol. 2024 Sep;178:111630. doi: 10.1016/j.ejrad.2024.111630. Epub 2024 Jul 15. PMID 39024662
• Shang-Guan ZX, Lin GT, Liu ZY, Zhong Q, Huang Q, Li P, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Zheng HL, Zheng CH, Lin JX, Huang CM. Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life after Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study. Obes Surg. 2024 May;34(5):1479-1490. doi: 10.1007/s11695-024-07146-z. Epub 2024 Mar 15. PMID 38489003
• Emamat H, Jamshidi A, Farhadi A, Ghalandari H, Ghasemi M, Tangestani H. The association between the visceral to subcutaneous abdominal fat ratio and the risk of cardiovascular diseases: a systematic review. BMC Public Health. 2024 Jul 9;24(1):1827. doi: 10.1186/s12889-024-19358-0. PMID 38982435
• Neeland IJ, Ross R, Despres JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH; International Atherosclerosis Society; International Chair on Cardiometabolic Risk Working Group on Visceral Obesity. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet PMID 31301983

Идентификаторы

NCT: NCT07711925 · 53/2025

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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