Идёт набор NCT07709182

Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients

Без фазы С лечением Airway Occlusion Pressure Pressure Support Ventilation Conventional Management Weaning Window Patients

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Pressure support ventilation protocol, Airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV).
Кому может быть актуально: Состояния в реестре: Airway Occlusion Pressure, Pressure Support Ventilation, Conventional Management, Weaning Window Patients. Базовые параметры: от 21 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Египет
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients: A Randomized Controlled Trial

Обзор

This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.

Подробное описание

Mechanical ventilation is an essential modality for critically ill patients with acute respiratory failure. It supports gas exchange and reduces respiratory muscle workload, but prolonged use increases the risk of lung injury, diaphragm dysfunction, and infection. Therefore, the process of ventilator weaning is crucial in optimizing patient outcomes.

Airway occlusion pressure (P0.1), the negative pressure generated 100 ms after the onset of inspiration during an occluded breath, provides a direct measurement of patient respiratory drive independent of lung mechanics. It is a strong indicator of ventilatory demand and drive-load imbalance.

Pressure Support Ventilation (PSV) is commonly used during the weaning window, but conventional titration methods rely on clinical assessment alone. These methods do not reliably identify asynchronous events such as ineffective effort, double triggering, or premature cycling, which prolong ventilation.

Вмешательства

Другое Pressure support ventilation protocol
Patients will receive a conventional pressure support ventilation protocol.
Другое Airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV)
Patients will receive airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV).

Первичные конечные точки

Ventilator-Free Days [Срок оценки: Day 28 after the procedure]

Вторичные конечные точки (5)

Duration of Mechanical Ventilation [Срок оценки: Till final successful extubation (Up to 48 hours)]
Length of stay in the intensive care unit [Срок оценки: Till the discharge from intensive care unit (Up to 28 days)]
Patient-Ventilator Asynchrony Index (PVAI) [Срок оценки: Day 28 after the procedure]
Dexmedetomidine requirement [Срок оценки: Day 28 after the procedure]
Failed weaning [Срок оценки: 48 hours after extubation]

Критерии участия

Критерии включения

Mechanically ventilated adult patients ≥ 21 years.
Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.
Hemodynamically stable \[mean arterial pressure (MAP) ≥60 mmHg\].
All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.