The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer

Официальное название

Postoperative Endoscopic Polyp Recurrence Correlation With Pathological Status Classification of Colorectal Cancer: a Multicenter, Retrospective Cohort Open-label Study

Обзор

Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study

Подробное описание

This study aims to address the gaps in existing research by focusing on the high-risk group of colorectal cancer patients post-radical surgery, systematically reviewing potential factors influencing polyp recurrence, further clarifying independent risk factors for postoperative polyp recurrence in this population, and constructing a predictive model that better aligns with the clinical needs of such patients, thereby providing more precise references for developing personalized follow-up strategies in clinical practice.

Вмешательства

• Процедура Endoscopic polypectomy
  Endoscopic polypectomy

Первичные конечные точки

• Adenoma recurrence after colorectal surgery [Срок оценки: Postoperative；follow up till 5 years]
• Colitisafter colorectal surgery [Срок оценки: Postoperative；follow up till 5 years]

Критерии участия

Критерии включения

Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects. Inclusion criteria:

Diagnosed with colon cancer through histopathological examination ; Undergoing radical R0 resection ； Complete Colonoscopy follow-up after surgery less than 12 months.

Критерии исключения

With adenomatous polyposis , Lynch syndrome and Peutz-Jeghers syndrome； Combined inflammatory bowel disease; Polyp were present before surgery and have not been completely removed； With distant metastasis or local recurrence； Clinical data is missing and can not be analyzed.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Gansu provincial hospital — Lanzhou

Публикации

• Galjart B, Hoppener DJ, Aerts JGJV, Bangma CH, Verhoef C, Grunhagen DJ. Follow-up strategy and survival for five common cancers: A meta-analysis. Eur J Cancer. 2022 Oct;174:185-199. doi: 10.1016/j.ejca.2022.07.025. Epub 2022 Aug 27. PMID 36037595
• IJspeert JEG, Bretthauer M, Jover R, Dekker E; Dutch colonoscopy surveillance working group. Balancing benefit and burden: rethinking post-polypectomy colonoscopy surveillance strategies. Lancet Gastroenterol Hepatol. 2026 Aug;11(8):720-726. doi: 10.1016/S2468-1253(26)00128-7. Epub 2026 Jun 19. PMID 42320508
• Ebert MP, Reichermeier S, Klug L, Lynen Jansen P, Pox C. Clinical Practice Guideline: Colorectal Cancer-Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care. Dtsch Arztebl Int. 2025 Dec 26;122(26):729-734. doi: 10.3238/arztebl.m2025.0196. Epub 2025 Dec 26. PMID 41195479
• Laven-Law G, Symonds EL, Simpson K, Coats M, De Silva M, Hollington P, Cock C, Wassie MM. Risk of Advanced Colorectal Neoplasia at Follow-up Colonoscopy After Synchronous Adenoma and Clinically Significant Serrated Polyp. Clin Gastroenterol Hepatol. 2026 Feb;24(2):544-553. doi: 10.1016/j.cgh.2025.07.023. Epub 2025 Aug 5. PMID 40774589

Идентификаторы

NCT: NCT07708415 · Colorectal cancer and polyp

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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