Pilates Exercises Versus Intermittent Fasting Diet on Physical and Metabolic Aging Process in Obese Perimenopausal Women
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Pilates exercise, Intermittent Fasting Diet.
- Кому может быть актуально
- Состояния в реестре: Obesity. Базовые параметры: 40 лет — 45 лет · Женщины.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Египет
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Effect of Pilates Exercises Versus Intermittent Fasting Diet on Physical and Metabolic Aging Process in Obese Perimenopausal Women
Обзор
This study aims to compare the effect of pilates exercises versus intermittent fasting diet on physical and metabolic aging parameters in obese perimenopausal women.
Подробное описание
Obesity is associated with a shorter life expectancy, partly due to its role in accelerating the aging process. The conditions and comorbidities linked to obesity mirror those of age-related diseases. Individuals with obesity are at a higher risk for various age-related conditions, including cardiovascular disease (CVD), hypertension, type 2 diabetes mellitus (T2DM), and cance.
Aging is a natural part of the human life cycle, characterized by a gradual loss of physiological integrity, leading to functional decline and increased vulnerability to mortality. Alongside the onset of age-related diseases in older adults, common aging phenotypes, such as redox imbalance, mitochondrial dysfunction, increased apoptosis, cellular senescence, insufficient autophagy, and chronic inflammation, are observed in both humans and animals. Similar mechanisms underpin the onset of age-related diseases in obesity and excessive calorie intake, suggesting that obesity accelerates aging through these interconnected pathways.
Pilates has gained popularity as a holistic exercise approach that emphasizes respiration, body control, and movement precision. Current research supports the positive effects of Pilates on respiratory muscle strength, balance, overall physical performance, and quality of life. Additionally, a recent systematic review and meta-analysis concluded that Pilates is an effective alternative for improving maximal oxygen uptake (VO2max) values.
Fasting, which involves abstaining from food for extended periods ranging from hours to days, triggers significant metabolic changes referred to as the 'metabolic switch'. One of the most important metabolic shifts during fasting is the increased production of ketone bodies, such as acetoacetic acid, β-hydroxybutyric acid (β-HB), and acetone, in the liver.
Given the heightened vulnerability of obese perimenopausal women to accelerated aging processes and metabolic dysfunction, there is a critical need to identify the most effective lifestyle interventions for this high-risk population. While both Pilates exercise and intermittent fasting show promise in addressing aging-related parameters through different mechanisms, no direct comparative studies have evaluated their relative efficacy on comprehensive physical and metabolic aging markers in obese perimenopausal women.
Вмешательства
- Другое Pilates exercise
Each exercise will be ranged from 1 to 3 minutes, with a break of 10 seconds. The exercises include: Flat Abs: Pilates Hundred; Flat Abs: Roll-Up; Obliques: Twist and Reach; Lower Back: Shoulder Bridge; Lower Body: Kneeling Side Kicks; Lower Body: Leg Swings; Stamina: Wall Chair. - Другое Intermittent Fasting Diet
This fasting regimen involves fasting for 16 hours each day and limiting eating to an 8-hour window. The 16:8 intermittent fasting protocol is relatively straightforward. It divides the day into two main periods: the fasting period which is 16 hours and the 8 hours eating window .
Первичные конечные точки
- Body weight [Срок оценки: 12 weeks]
- Body mass index [Срок оценки: 12 weeks]
- Waist circumference [Срок оценки: 12 weeks]
- Hip circumference [Срок оценки: 12 weeks]
- Waist-hip ratio [Срок оценки: 12 weeks]
- Resting Heart Rate Measurement [Срок оценки: 12 weeks]
- Maximum Heart Rate [Срок оценки: 12 weeks]
- Maximum oxygen consumption (VO2 max) [Срок оценки: 12 weeks]
Вторичные конечные точки (6)
- Assessment of the health-related quality of life [Срок оценки: 12 weeks]
- Total cholesterol (TC) [Срок оценки: 12 weeks]
- Triglycerides [Срок оценки: Normal: <150 mg/dL (<1.7 mmol/L)]
- High-density lipoprotein [Срок оценки: 12 weeks]
- Low-density lipoprotein [Срок оценки: 12 weeks]
- Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) [Срок оценки: 12 weeks]
Критерии участия
Критерии включения
- Their body mass index will be ranged from 30 to 35 kg/m2.
- Waist hip ratio will be > 1.
- Total cholesterol (TC) will be > 200 mg/dl.
- Triglycerides (TG) will be > 150 mg/dl.
- Low-density lipoprotein (LDL) will be > 100 mg/dl.
- High-density lipoprotein (HDL) will be < 40 mg/dl.
Критерии исключения
- Diabetes type I.
- Concomitant cardiac disorders.
- Pregnant or breastfeeding.
- Eating disorders as Anorexia.
- Thyroid disorders.
- Kidney disorders.
- Severe joint issues as arthritis and post-joint replacement.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Рандомизированное
- Модель
- Параллельные группы
- Маскирование
- Простое слепое
- Основная цель
- Лечение
Центры проведения
Египет · 1 центр
- Hadeel Adil Mohamed — Al Fayyum
Идентификаторы
NCT: NCT07683286 · P.T.REC/012/006542