Набор скоро начнётся NCT07678528

Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE

Без фазы С лечением Aging Disorder

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Exposome assessment.
Кому может быть актуально: Состояния в реестре: Aging Disorder. Базовые параметры: от 55 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.

Вмешательства

Другое Exposome assessment
Visit 1: blood sample, questionnaires on the personal exposome (lifestyle habits (e.g., physical activity, diet, stress) and social characteristics and health status) \| ii) Outpatient assessment: wearing a silicone bracelet for 7 days to measure external environmental exposure to pollutants and quantify physical activity \| iii) Visit 2: 1-year follow-up of health status

Первичные конечные точки

Frailty (health measure) [Срок оценки: at baseline and 12 months later]

Вторичные конечные точки (12)

Functional and health status [Срок оценки: at baseline and 1 year]
Physical functional capacities (health measure) [Срок оценки: at baseline and at 12 months]
Quality of life (health measure) [Срок оценки: at baseline and 12 months]
Autonomy (health measure) [Срок оценки: at baseline and 12 months]
Comorbidity (health measure) [Срок оценки: at baseline and 12 months]
Pollutant metabolites (internal exposome/biological measure) [Срок оценки: at baseline.]
DNA and telomere damage (internal exposome/biological measure) [Срок оценки: at baseline.]
exposure to air pollutants (external environmental exposome measure) [Срок оценки: at baseline]
exposure to pesticides, hydrocarbons, plastics, flame retardant pollutants (external environmental exposome measure) [Срок оценки: at baseline]
Smoking habits (external personal exposome measure) [Срок оценки: at baseline.]
Alcohol habits (external personal exposome measure) [Срок оценки: at baseline]
Self-reported physical activity habits (external personal exposome measure) [Срок оценки: at baseline]

Критерии участия

Критерии включения

Aged 55 or over
Affiliated with or beneficiaries of a social security scheme
Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende