Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia

Официальное название

Effects of a Chatbot-Based Intervention on Resting-State Functional Connectivity and Spontaneous Neural Activity in Individuals With Anhedonia

Обзор

The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive symptoms. The study will use a randomized active-control intervention design with pre- and post-intervention resting-state functional magnetic resonance imaging assessments.

Подробное описание

Anhedonia represents a core characteristic of depression and is characterized by reduced experience of pleasure. It is closely related to decreased motivation, altered reward processing, and alterations in intrinsic brain network function. Resting-state fMRI provides a way to examine intrinsic brain activity and functional connectivity without requiring participants to perform a specific task. This is important because changes associated with anhedonia may not only appear during reward-related tasks, but may also be reflected in spontaneous brain network organization.

Вмешательства

• Поведенческое MI Chatbot Interaction
  The experimental chatbot is designed to use principles of Motivational Interviewing to support participants in exploring their personal values, motivation for change, and daily behavioral goals related to pleasure, engagement, and reward-seeking. During the intervention period, participants will interact with the chatbot regularly through brief text-based conversations. The chatbot will provide empathic, non-judgmental responses, encourage reflection on current difficulties, and help participant
• Поведенческое Active Control Chatbot Interaction
  Participants will interact with a chatbot matched in format and frequency of use. This chatbot will provide neutral nature-related stories or general natural history content. It will be designed to maintain participant engagement while avoiding therapeutic techniques, motivational interviewing strategies, behavioral activation guidance, or personalized mental health advice. This active control condition will help control for nonspecific effects of chatbot interaction, attention, expectancy, and

Первичные конечные точки

• Intervention-Related Changes in Resting-State Functional Connectivity After the Intervention [Срок оценки: Baseline before the first chatbot interaction and Week 1 after completion of the chatbot intervention.]

Вторичные конечные точки (1)

• Intervention-Related Changes in Spontaneous Activity After the Intervention [Срок оценки: Baseline before the first chatbot interaction and Week 1 after completion of the chatbot intervention.]

Критерии участия

Критерии включения

• 18-40 years
• Right-handed
• Normal or corrected normal visual acuity
• Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 22 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory

Критерии исключения

• History of major central nervous system disorders, such as epilepsy, traumatic brain injury, stroke, or brain tumors.
• History of severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, or other psychotic disorders.
• History of substance or alcohol use disorder or substance or alcohol misuse within the past 12 months that may affect study participation or outcome assessment.
• Individuals currently at high risk of suicide, severe self-harm, or experiencing an acute psychiatric crisis.
• Individuals who are currently using psychiatric medications or have undergone psychotherapy within the past 4 weeks that may significantly affect mood, motivation, or reward processing.
• Severe vision or hearing impairments that cannot be corrected and would interfere with task performance.
• Contraindications to MRI scanning, including metallic implants, pacemakers, severe claustrophobia, or other conditions incompatible with MRI.
• Pregnancy or breastfeeding.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Фундаментальное исследование

Центры проведения

Китай · 1 центр

• University of Electronic Science and Technology of China — Чэнду

Идентификаторы

NCT: NCT07665216 · BAM_lab_MI_01

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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