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Набор по приглашению NCT07662954

Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes

Без фазы С лечением Oxidative Stress Inflammation Physical Fitness Echocardiography

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Spinning Training, Magnesium Supplementation.
Кому может быть актуально
Состояния в реестре: Oxidative Stress, Inflammation, Physical Fitness, Echocardiography. Базовые параметры: 18 лет — 30 лет · Мужчины.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Turkey (Türkiye)
Следующий шаг
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Официальное название

Effects of Magnesium Supplementation and Spinning Training on Cardiac Function, Oxidative Stress, Inflammation, and Aerobic Capacity

Обзор

Regular aerobic exercise may improve cardiorespiratory fitness while modulating systemic inflammation and oxidative stress. Spinning, as a structured indoor cycling modality, provides a practical aerobic exercise model with adjustable intensity and duration, but its effects on redox balance, inflammatory status, aerobic capacity, and cardiac functional parameters may vary according to individual recovery and nutritional status. Magnesium is an essential micronutrient involved in energy metabolism, muscle contraction-relaxation, ion regulation, and inflammatory and oxidative pathways; therefore, magnesium use may be relevant to exercise adaptation and recovery. This study aims to evaluate the associations of magnesium use and spinning training with oxidative stress, inflammation, aerobic capacity, and cardiac parameters. In this context, biochemical markers related to oxidative/antioxidant status and inflammation, aerobic performance indicators, and echocardiographic cardiac function parameters will be assessed together. The study is expected to provide real-world evidence on whether magnesium use in individuals participating in spinning training is associated with more favorable redox, inflammatory, aerobic, and cardiac profiles.

Вмешательства

  • Поведенческое Spinning Training
    Participants will participate in a structured spinning training program during the study period. The program will consist of supervised indoor cycling sessions performed at a planned frequency, duration, and intensity.
  • Пищевая добавка Magnesium Supplementation
    Participants will receive oral magnesium supplementation during the study period in addition to the structured spinning training program.

Первичные конечные точки

  • Change in Maximal Oxygen Uptake (VO₂max) [Срок оценки: Baseline and 6 weeks]
  • Change in Serum Magnesium Concentration [Срок оценки: Baseline and 6 weeks]
Вторичные конечные точки (11)
  • Change in Total Antioxidant Status (TAS) [Срок оценки: Baseline and 6 weeks]
  • Change in Total Oxidant Status (TOS) [Срок оценки: Baseline and 6 weeks]
  • Change in Paraoxonase-1 Activity (PON1) [Срок оценки: Baseline and 6 weeks]
  • Change in Arylesterase Activity (ARE) [Срок оценки: Baseline and 6 weeks]
  • Change in High-Sensitivity C-Reactive Protein (hs-CRP) [Срок оценки: Baseline and 6 weeks]
  • Change in Interleukin-6 (IL-6) [Срок оценки: Baseline and 6 weeks]
  • Change in Tumor Necrosis Factor-Alpha (TNF-α) [Срок оценки: Baseline and 6 weeks]
  • Change in Serum Potassium Concentration [Срок оценки: Baseline and 6 weeks]
  • Change in Serum Calcium Concentration [Срок оценки: Baseline and 6 weeks]
  • Change in N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) [Срок оценки: Baseline and 6 weeks]
  • Change in Left Ventricular Ejection Fraction (LVEF) [Срок оценки: Baseline and 6 weeks]

Критерии участия

Критерии включения

  • Self-identified male participants
  • Aged 18 to 30 years
  • Physically active individuals
  • Participants who are eligible to participate in a structured spinning training program
  • Participants with available baseline and follow-up assessments for biochemical, aerobic capacity, and cardiac function parameters

Критерии исключения

  • Presence of any chronic systemic disease
  • Acute infection during the study period
  • Regular use of anti-inflammatory or antioxidant medications
  • Use of antioxidant or ergogenic supplements other than magnesium
  • Any cardiovascular, musculoskeletal, or neurological condition that may limit participation in spinning training
  • Missing baseline or follow-up outcome data

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Параллельные группы
Маскирование
Простое слепое
Основная цель
Фундаментальное исследование

Центры проведения

Turkey (Türkiye) · 1 центр
  • Karamanoğlu Mehmetbey University, Faculty of Sport Sciences — Karaman

Публикации

  • Tarsitano MG, Quinzi F, Folino K, Greco F, Oranges FP, Cerulli C, Emerenziani GP. Effects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review. J Transl Med. 2024 Jul 5;22(1):629. doi: 10.1186/s12967-024-05434-x. PMID 38970118
  • Sireno L, Dimauro I, Caporossi D. Reactive oxygen species in exercise biology: from adaptive stress response to cell signaling and beyond. Free Radic Biol Med. 2026 Mar 1;245:447-462. doi: 10.1016/j.freeradbiomed.2025.12.044. Epub 2026 Jan 2. No abstract available. PMID 41485544
  • Reno AM, Green M, Killen LG, O'Neal EK, Pritchett K, Hanson Z. Effects of Magnesium Supplementation on Muscle Soreness and Performance. J Strength Cond Res. 2022 Aug 1;36(8):2198-2203. doi: 10.1519/JSC.0000000000003827. Epub 2020 Oct 1. PMID 33009349
  • Feng W, Wang Y, Gu X, Yu D, Liu Z. Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis. BMC Sports Sci Med Rehabil. 2025 Nov 28;17(1):360. doi: 10.1186/s13102-025-01327-8. PMID 41316311
  • Dominguez LJ, Veronese N, Ragusa FS, Baio SM, Sgro F, Russo A, Battaglia G, Bianco A, Barbagallo M. The Importance of Vitamin D and Magnesium in Athletes. Nutrients. 2025 May 13;17(10):1655. doi: 10.3390/nu17101655. PMID 40431395
  • Chavarrias M, Carlos-Vivas J, Collado-Mateo D, Perez-Gomez J. Health Benefits of Indoor Cycling: A Systematic Review. Medicina (Kaunas). 2019 Aug 8;55(8):452. doi: 10.3390/medicina55080452. PMID 31443139
  • Battista RA, Foster C, Andrew J, Wright G, Lucia A, Porcari JP. Physiologic responses during indoor cycling. J Strength Cond Res. 2008 Jul;22(4):1236-41. doi: 10.1519/JSC.0b013e318173dbc4. PMID 18545183

Идентификаторы

NCT: NCT07662954 · 02-2026/29

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗