The Green Room: Virtual Nature for Mental Well-being in the Acute Psychiatry Ward

THE GREEN ROOM is a sequential, explanatory mixed-methods study comprising two phases. Phase 1 is a qualitative study (n=40; patients and healthcare professionals) using the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework to identify barriers and facilitators to VR implementation in an acute psychiatric ward, and to co-create the final VR intervention content with patients and staff. Phase 2 is the randomised controlled trial described in this record.

Phase 2 participants are randomised 1:1 to receive VR-based nature exposure sessions (Nature Treks VR, Meta Quest 3) in addition to treatment as usual, or treatment as usual alone. Randomisation is stratified by legal admission status (voluntary vs. involuntary) using two separate pre-generated sequential allocation lists (n=60 per stratum). Allocation concealment is maintained through sequential, pre-fixed assignment managed by the research assistant; the Principal Investigator remains blinded to individual allocations during data collection, and the statistical analyst remains blinded until the analysis plan is finalised and locked.

Intervention-group participants are offered VR sessions of 10\\u201315 minutes approximately every other day throughout hospitalisation, on a strictly voluntary basis. Participants may freely choose and switch between all nature environments available within the Nature Treks VR application. During the first VR session, a consecutive sub-sample of intervention participants (estimated n\\u224850) additionally undergo physiological monitoring (heart rate and heart rate variability) using a consumer-grade wearable device (Fitbit).

The primary analysis will use a mixed-design ANOVA (or ANCOVA with baseline score as covariate) to evaluate change in PSS-10 from admission to discharge, following an intention-to-treat approach. Missing data will be handled under a Missing-At-Random assumption within the mixed-effects model framework, with complete-case analysis as a sensitivity check. Two exploratory subgroup analyses are pre-specified: by legal admission status and by primary diagnostic category.

• World Health Organization-Five Well-Being Index (WHO-5) score [Срок оценки: Through study completion, an average of 2 weeks]
• Views On Inpatient Care (VOICE) score [Срок оценки: Through study completion, an average of 2 weeks]
• Client's Assessment of Treatment (CAT) score [Срок оценки: Through study completion, an average of 2 weeks]
• Length of hospital stay [Срок оценки: From admission to discharge, an average of 2 weeks]
• Rate of discharge against medical advice (DAMA) [Срок оценки: Throughout hospitalization, an average 2 weeks.]
• State-Trait Anxiety Inventory - State subscale (STAI-S) score [Срок оценки: Day 1]
• Positive and Negative Affect Schedule (PANAS) score [Срок оценки: Day 1]
• System Usability Scale (SUS) score [Срок оценки: Day 1]
• Simulator Sickness Questionnaire (SSQ) total severity score [Срок оценки: Day 1]
• Percentage of offered VR sessions accepted [Срок оценки: Throughout hospitalization (intervention group only) an average 2 weeks.]