Improving the Reliability of LLMs as Medical Assistants for the General Public

Официальное название

Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial

Обзор

This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Подробное описание

This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.

Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Вмешательства

• Поведенческое three minutes six dimensions education
  3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting. Guided by cognitive load theory and the natural process physicians use to take medical histories, the investigators identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process
• Другое ChatGPT
  Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
• Другое Gemini
  Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.

Первичные конечные точки

• Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group [Срок оценки: 1 hour.]
• Disposition concordance of the 3M-6D education GPT group compared with the GPT group [Срок оценки: 1 hour.]
• Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group [Срок оценки: 1 hour.]
• Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group [Срок оценки: 1 hour.]

Вторичные конечные точки (12)

• Relevant conditions identification of the 3M-6D education GPT group compared with the control group [Срок оценки: 1 hour.]
• Relevant conditions identification of the 3M-6D education Gemini group compared with the control group [Срок оценки: 1 hour.]
• Disposition concordance of the 3M-6D education GPT group compared with the control group [Срок оценки: 1 hour.]
• Disposition concordance of the 3M-6D education Gemini group compared with the control group [Срок оценки: 1 hour.]
• Red-flag identification in the 3M-6D education GPT group compared with the GPT group [Срок оценки: 1 hour.]
• Red-flag identification in the 3M-6D education GPT group compared with the control group [Срок оценки: 1 hour.]
• Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group [Срок оценки: 1 hour.]
• Red-flag identification in the 3M-6D education Gemini group compared with the control group [Срок оценки: 1 hour.]
• NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group [Срок оценки: 1 hour.]
• NASA Task Load Index score of the 3M-6D education GPT group compared with the control group [Срок оценки: 1 hour.]
• NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group [Срок оценки: 1 hour.]
• NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group [Срок оценки: 1 hour.]

Критерии участия

Критерии включения

• Age 18 years or greater, male or female;
• Completed primary school or higher education;
• Able to use a smartphone or computer to complete online interaction;
• No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
• Able to understand and comply with study procedures and to provide written informed consent.

Критерии исключения

• Currently or previously employed as a healthcare worker;
• Previously received systematic medical training;
• Currently involved in concurrent research that may interfere with the results of the present trial;
• The investigator considered that the participant had other conditions that might affect compliance or preclude participation.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Организация здравоохранения

Центры проведения

Китай · 1 центр

• Beijing Ctiy — Пекин

Идентификаторы

NCT: NCT07651280 · LAMP-1

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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