Набор скоро начнётся NCT07636083

Acute Kidney Injury in Upper GI Bleeding Patients

— Наблюдательное Upper Gastrointestinal Bleeding Acute Kidney Injury

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Observational assessment.
Кому может быть актуально: Состояния в реестре: Upper Gastrointestinal Bleeding, Acute Kidney Injury. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Египет
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Acute Kidney Injury Following Upper Gastrointestinal Bleeding: Incidence and Predictors

Обзор

This study aims to evaluate the incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB) at Sohag University Hospitals, and to identify predictors associated with renal impairment in these patients.

Подробное описание

Upper gastrointestinal bleeding (UGIB) is a common medical emergency associated with significant morbidity and mortality. Acute kidney injury (AKI) is frequently observed in these patients, mainly due to hypovolemia and renal hypoperfusion. Despite its clinical importance, data regarding AKI incidence and predictors in UGIB patients, particularly in Middle Eastern populations, remain limited.

This prospective observational study aims to assess renal function abnormalities and identify predictors of AKI in patients with UGIB, including both variceal and non-variceal causes. The study will also evaluate clinical outcomes such as mortality, hospital stay duration, and need for renal replacement therapy.

Вмешательства

Другое Observational assessment
No therapeutic intervention is applied. Patients are managed according to standard hospital care, and data are collected observationally.

Первичные конечные точки

Incidence of Acute Kidney Injury (AKI) According to KDIGO Criteria [Срок оценки: From hospital admission through hospital discharge, up to 30 days]

Вторичные конечные точки (2)

Percentage of Patients Developing AKI According to Bleeding Etiology [Срок оценки: Baseline (hospital admission) with AKI occurrence assessed through hospital discharge, up to 30 days]
Change in Serum Creatinine Concentration [Срок оценки: Through hospital discharge, up to 30 days]

Критерии участия

Критерии включения

Adult patients aged 18 years or older
Patients presenting with clinical features suggestive of acute upper gastrointestinal bleeding (UGIB), including hematemesis, coffee-ground vomiting, or melena
Diagnosis of UGIB confirmed by upper gastrointestinal endoscopy or strong clinical evidence when endoscopy is not immediately available
Patients admitted to Sohag University Hospitals (medical wards or intensive care unit)
Availability of renal function data, including at least one serum creatinine measurement at admission and serial measurements during hospitalization
Availability of baseline renal function (previous serum creatinine within 3-12 months) or estimable baseline during hospitalization

Критерии исключения

Patients with end-stage renal disease (ESRD) on chronic dialysis
Patients with a history of renal transplantation
Patients with advanced chronic kidney disease stage 5 (eGFR <15 mL/min/1.73 m²) not on dialysis
Patients with lower gastrointestinal bleeding
Patients with incomplete or missing essential renal function data
Patients discharged or deceased within 24 hours of hospital admission
Pregnant patients
Patients with acute kidney injury at presentation due to causes other than UGIB

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет