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Набор скоро начнётся NCT07634250

Mental Health and Periodontitis in Probable Bruxers

Наблюдательное Periodontal Disease

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Periodontal Disease. Базовые параметры: 30 мес. — 50 мес. · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Индия
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Официальное название

Association Between Mental Health Status and Periodontitis Among Probable Bruxers

Обзор

The goal of this observational study is to learn how mental health affects periodontal health in people having teeth grinding (bruxism). The main questions it aims to answer are: Does poor mental health increase the risk of periodontitis in people with teeth grinding? Does stress link teeth grinding and periodontitis? Participants are people who likely have teeth grinding(bruxism) and periodontitis Participants will: Answer questions about their mental health, including stress Get a periodontal health status check Teeth grinding(Bruxism) can occur due to stress, smoking, alcohol use, and bite problems. Stress may affect muscle activity and lead to teeth grinding. It can also weaken the body's defense and lead to poor oral care. This may worsen periodontal health.

Подробное описание

Stress is related to emotional and physiological reactions when there is a lifetime event conflict that exceeds the individual's ability to deal effectively with the situation.

Psychological stress is generally recognized as a potential cofactor in the pathogenesis of infectious disease. It can trigger immune responses that favor the occurrence or exacerbation of changes in the oral cavity, such as periodontitis. It can directly impair the periodontal status through various biological mechanisms: variation in the gingival fluid, production of interleukin IL1, IL-6, reduction of polymorphonuclear leukocytes and phagocytosis, and decreased lymphocyte production and antibody production, as well as through changes in behavior related to health, such as oral hygiene, smoking habit and diet.

Stress evokes emotional and physiologic reactions and is an important modifiable risk factor for both mental and physical illnesses.

Periodontitis is characterized by progressive destruction of the tooth-supporting apparatus causing loss of support which manifests through clinical attachment loss (CAL), radiographically assessed alveolar bone loss, presence of periodontal pocket and gingival bleeding.

Based on the ecologic plaque hypothesis, periodontal diseases result from environmental changes to the oral habitat. Marsh considers that the selection of ''pathogenic'' bacteria is directly coupled to changes in the environment.

A sound understanding of the psychosocial pathways of the behaviors strongly linked to periodontal diseases, and how psychological factors affect the response of the periodontal tissues to pathogens, is essential for diagnosis and improving interventions.

One of the stress manifestations is bruxism, or gnashing and grinding of the teeth. Theories about the origin of bruxism have hypothesized different types of factors: peripheral, connected to teeth occlusion interferences, central, connected to neurotransmission from brain to chewing muscles and psychosocial, associated to stress.

"Although extensive research has investigated the associations between stress and bruxism, as well as stress and periodontitis, there remains a notable gap in the literature examining the combined relationship among stress, bruxism, and periodontitis."

Первичные конечные точки

  • mental health status [Срок оценки: baseline]
Вторичные конечные точки (5)
  • pocket probing depth [Срок оценки: baseline]
  • Clinical Attachment Level [Срок оценки: Baseline]
  • Bleeding on probing [Срок оценки: baseline]
  • Gingival Index [Срок оценки: Baseline]
  • Plaque Index [Срок оценки: Baseline]

Критерии участия

Критерии включения

  • Adult periodontitis patients with age group 30-50 years diagnosed with probable bruxism.
  • Presence of minimum 20 teeth excluding third molars.

Критерии исключения

  • History of systemic disease such as diabetes or autoimmune disease
  • History of drugs having the potential impact on periodontal status like phenytoin, cyclosporin, calcium-channel blockers or antidepressant drugs.
  • Pregnant or lactating females.
  • Post-menopausal women.
  • Patients diagnosed with temporomandibular disorders- pain and tenderness in the masticatory muscles

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Другое

Центры проведения

Индия · 1 центр
  • Pgids, Rohtak — Rohtak

Идентификаторы

NCT: NCT07634250 · VARSHA PERIO

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗