THE EFFECT OF AEROBIC AND RESISTANCE TRAINING ON THE IMMUNE SYSTEM

Официальное название

AEROBİC AND RESİSTANCE TRAİNİNG EFFECTS ON INFLAMMATORY AND IMMUNE BİOMARKERS İN YOUNG SEDENTARY WOMEN

Обзор

Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.

Подробное описание

The effects of exercise on the immune system have been studied for many years. Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response. Regular exercise has been shown to increase individuals' physical fitness levels. Exercise is used in the prevention and treatment of various diseases. Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health. Regular exercise positively affects all systems of the organism, including the immune system. Changes in the immune system after acute and chronic exercise differ. The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals. While light to moderate exercise strengthens the immune system, intense exercise can suppress it. The effects of exercise on the immune system have been the subject of much research in recent years. However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood. Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system. In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response. This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation. Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels. The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.

Вмешательства

• Поведенческое Aerobic and resistance exercise
  Because it was done on young girls who lead a sedentary lifestyle.

Первичные конечные точки

• Change in C-Reactive Protein (CRP) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Interleukin-6 (IL-6) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Salivary Immunoglobulin A (IgA) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Immunoglobulin M (IgM) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Immunoglobulin G (IgG) Levels [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]
• Change in Leukocyte (WBC) Count [Срок оценки: Baseline (Week 0) and Post-intervention (Week 6)]

Критерии участия

Критерии включения

• University students aged 18-30
• Individuals who have engaged in recreational exercise at least two days a week for the past three months
• Those with low or no smoking or alcohol consumption who volunteer to participate in the study.

Критерии исключения

• Individuals who have had an infection or chronic illness in the last 6 months,
• Those with a history of autoimmune disease,
• Metabolic syndrome, or cardiovascular disease,
• Those who have used antibiotics or anti-inflammatory drugs in the last 3 months,
• Those who have suffered a serious injury during exercise or are unable to continue are not eligible.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Профилактика

Центры проведения

Turkey (Türkiye) · 1 центр

• İnönu University — Malatya

Публикации

• Nash D, Hughes MG, Butcher L, Aicheler R, Smith P, Cullen T, Webb R. IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Scand J Med Sci Sports. 2023 Jan;33(1):4-19. doi: 10.1111/sms.14241. Epub 2022 Oct 8. PMID 36168944
• Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, Leigh TM, Carter P, Davies MJ. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013 Oct 29;8(10):e78350. doi: 10.1371/journal.pone.0078350. eCollection 2013. PMID 24205208
• Coughlin GH, Antush MT, Vella CA. Associations of sedentary behavior and screen time with biomarkers of inflammation and insulin resistance. J Behav Med. 2024 Oct;47(5):828-838. doi: 10.1007/s10865-024-00498-y. Epub 2024 May 25. PMID 38796664
• Thomas NE, Williams DR. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008 Oct;18(5):543-56. doi: 10.1111/j.1600-0838.2008.00824.x. Epub 2008 Jul 9. PMID 18627553
• Dogra S, Wolf M, Jeffrey MP, Foley RCA, Logan-Sprenger H, Jones-Taggart H, Green-Johnson JM. Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults. BMC Sports Sci Med Rehabil. 2019 Oct 18;11:23. doi: 10.1186/s13102-019-0138-4. eCollection 2019. PMID 31636910

Идентификаторы

NCT: NCT07632911 · 11/03/2025-7252

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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