Effect of Dance-based Multimodal Exercise for Managing CIPN in Cancer Patients

Официальное название

Effects of Dance-based Multimodal Exercise Programme for Managing Chemotherapy-induced Peripheral Neuropathy in Patients With Solid Tumors: A Pilot Randomized Controlled Study

Обзор

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant and distressing symptom experienced by cancer patients with different cancer types. Systematic reviews demonstrate that exercise is an effective non-pharmacological strategy for managing chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients. Multimodal exercise was found to be superior to a single-modality exercise programme. However, the lack of using Information-Motivation-Behavioral Skill (IMB) model and addressing the social motivation component in current multimodal exercise programmes for cancer patients with solid tumors. Objectives: This study aims to evaluate the effects of a 6-week dance-based multimodal exercise program on CIPN symptoms over a 3-month period, comparing outcomes with usual care in cancer patients with solid tumors. Methods: An assessor-blinded pilot randomized controlled trial with process evaluation will be conducted at Community Cancer Centers/ Community Centers and Non-governmental organizations. A total of 76 participants will be recruited, with both intervention and control groups receiving educational booklets and logbooks. The intervention group will engage in a 6-week dance-based multimodal exercise program, supplemented by goal-setting evaluations and motivational messaging. The control group will receive weekly exercise videos and motivational messages. Outcomes, including CIPN severity, quality of life, pain, balance, exercise knowledge, motivation, self-efficacy, and adverse effects, will be measured using validated tools at baseline, immediately post-intervention, 4 weeks post-intervention, and 12 weeks post-intervention. Process evaluation will explore perceived benefits, program awareness, and facilitators and barriers to adherence. Conclusion: This study aims to provide an evidence-based approach for managing CIPN in cancer patients through a dance-based multimodal exercise program. It underscores the importance of incorporating the IMB model to enhance exercise adherence and support self-management of CIPN in cancer survivors.

Вмешательства

• Поведенческое dance-based multimodal exercise
  This study applies the Information-Motivation-Behavioral Skills (IMB) model in a six-week Zumba Gold dance program for cancer survivors. Each weekly 75-minute session includes vital sign checks, 50 minutes of multimodal exercise (warm-up, workout, cool-down), and group sharing. Dance styles taught are Merengue, Salsa, Cumbia, Belly dance, Flamenco, Tango, and cool-down, with revision in later sessions. Videos with safety guidance are shared via WhatsApp for home practice. Chair-based options are
• Поведенческое Exercise education
  Control group participants will receive an educational booklet and logbook, plus weekly WhatsApp exercise videos recommended by the Department of Health, HKSAR (Elderly Health Service, 2025) during the first six weeks. They are encouraged to follow NCCN and ACSM guidelines for cancer survivors: at least 150 minutes of moderate activity weekly, or 75 minutes vigorous, with warm-up and stretching before sessions. Stretching should occur on two non-resistance days, and resistance training 2-3 times

Первичные конечные точки

• Chemotherapy-induced peripheral neuropathy. [Срок оценки: from enrollment to 12 weeks after the intervention]

Вторичные конечные точки (5)

• Neuropathic pain [Срок оценки: from enrollment to 12 weeks after the intervention]
• Quality of Life in cancer patients [Срок оценки: from enrollment to 12 weeks after the intervention]
• Anxiety [Срок оценки: from enrollment to 12 weeks after intervention]
• Balance [Срок оценки: from enrollment to 12 weeks after intervention]
• Knowledge of exercise, exercise motivation and exercise self-efficacy [Срок оценки: from enrollment to 12 weeks after intervention]

Критерии участия

Критерии включения

• Patients was diagnosed with malignant solid tumor (s) which is defined as abnormal, cancerous masses of tissue, for example, all carcinomas (such as breast cancer, stomach cancer, colorectal cancer and gynecological cancer, lung cancer and so on), sarcomas and lymphomas
• Patients experience CIPN symptoms
• Patients are able to use smart phone and WhatsApp
• Patients are able to read or understand Chinese.

Критерии исключения

• Cancer patients suffer from severe organ failure or diseases that limit their level of activity
• Patients are diagnosed with non-chemotherapy induced peripheral neuropathy, such as sciatica and diabetic neuropathy
• Patients receive treatments that affect the severity of neuropathy, such as steroid, anticonvulsants and antidepressants
• Patients age below 18 years old
• Patients have cognitive impairments.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Другое

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

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Идентификаторы

NCT: NCT07632482 · 2026.192

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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