Systemic Inflammatory Markers In Vocal Cord Lesions
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Laryngeal polyps, Laryngeal nodules, Laryngeal cysts, Reinke's edema.
- Кому может быть актуально
- Состояния в реестре: Laryngeal Lesions, Systemic Inflammatory Process. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Turkey (Türkiye)
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Comparison Of Sysstemic Inflammatory Markers And Panimmune-Inflammatory Values In Patients With Beningn, Premalingnant And Malingnant Vocal Cord Lesions
Обзор
The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Подробное описание
Benign laryngeal lesions are generally nodules, polyps, or cysts that form due to overuse of the voice or vocal cord trauma. Reinke's edema, also within this group, is a benign laryngeal condition characterized by the accumulation of gelatinous fluid in the superficial lamina propria of the vocal cords. It is usually associated with chronic irritation, particularly smoking, and is frequently seen in middle-aged individuals with a long history of tobacco use. Previous experimental studies have shown that cigarette smoke triggers inflammatory responses in vocal cord fibroblasts and increases the production of inflammatory mediators. The cellular and systemic inflammatory processes triggered by irritation due to chronic smoking are still not fully understood. In recent years, systemic inflammation markers derived from routine hemogram parameters have attracted attention as low-cost and reliable potential biomarkers in various inflammatory and neoplastic diseases. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), hemoglobin-eosinophil ratio (HEO), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), as well as more comprehensive indices reflecting both inflammatory and nutritional status such as Neutrophil-Albumin Ratio (NPAR) and HALP (Hemoglobin, Albumin, Platelet Ratio), are inexpensive and readily available indicators of systemic inflammation. However, a review of the literature reveals a lack of studies examining the relationship between benign and malignant laryngeal lesions and systemic inflammation through these comprehensive indices (PIV and NPAR). The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Вмешательства
- Другое Laryngeal polyps
Bening laryngeal lesions - Другое Laryngeal nodules
Bening laryngeal lesions - Другое Laryngeal cysts
Bening laryngeal lesions - Другое Reinke's edema
Bening laryngeal lesions - Другое Papillomas
Premalign laryngeal lesions - Другое Dysplasia
Premalign laryngeal lesions - Другое High-risk premalignant lesions
Premalign laryngeal lesions - Другое Malignant vocal cord lesions
Malign laryngeal lesions - Другое Asymptomatic smokers without vocal cord lesions
None laryngeal lesions
Первичные конечные точки
- Determining the diagnostic accuracy of PIV [Срок оценки: Postoperative 1 month]
Вторичные конечные точки (6)
- Determining the diagnostic accuracy of NLR [Срок оценки: Postoperative 1 month]
- Determining the diagnostic accuracy of PLR [Срок оценки: Postoperative 1 month]
- Determining the diagnostic accuracy of HEO [Срок оценки: Postoperative 1 month]
- Determining the diagnostic accuracy of SII [Срок оценки: Postoperative 1 month]
- Determining the diagnostic accuracy of NPAR [Срок оценки: Postoperative 1 month]
- Determining the diagnostic accuracy of HALP [Срок оценки: Postoperative 1 month]
Критерии участия
Критерии включения
- Patients aged 18 years and older
- Patients with a diagnosis of vocal cord lesion via endoscopic or surgical means
- Patients with complete blood count and albumin data in their hospital records
Критерии исключения
- Acute infection
- Autoimmune disease
- Other malignancy
- Steroid use
- Hematological disease
- Systemic inflammatory disease
- Missing laboratory data
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Случай-контроль
Центры проведения
Turkey (Türkiye) · 1 центр
- University of Health Sciences, Antalya Training and Research Hospital — Antalya
Публикации
- Pan L, Yu Z, Xiang WX, Sun SR, Li JX, Deng YK, Wang MC, Zhong JX, Huang K, Gao PS, Zhu LP, Yao Y, Liu Z. Cigarette smoke-induced epithelial cell ferroptosis promotes neutrophilic inflammation in patients with nasal polyps. J Allergy Clin Immunol. 2025 Jun;155(6):1882-1897. doi: 10.1016/j.jaci.2025.02.034. Epub 2025 Mar 12. PMID 40086488
- Guven DC, Erul E, Yilmaz F, Yasar S, Yildirim HC, Ercan F, Kaygusuz Y, Cayiroz K, Ucdal MT, Yesil F, Yazici G, Cengiz M, Gullu I, Aksoy S. The association between pan-immune-inflammation value and survival in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2023 May;280(5):2471-2478. doi: 10.1007/s00405-022-07804-x. Epub 2022 Dec 24. PMID 36565325
Идентификаторы
NCT: NCT07626125 · 7/14