Neural Mechanisms of Emotion-behaviour Interactions

Официальное название

Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks

Обзор

Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions. Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera. The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.

Вмешательства

• Другое Functional Magnetic Resonance Imaging (fMRI)
  Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.

Первичные конечные точки

• Brain activity in regions of interest [Срок оценки: Day 0]

Вторичные конечные точки (3)

• Brain activity during task 1 (Self-organization under threat) [Срок оценки: Day 0]
• Brain activity during task 2 (Self-organization and learning) [Срок оценки: Day 0]
• Brain activity during task 3 (Self-organization and social context) [Срок оценки: Day 0]

Критерии участия

Критерии включения

• 18-45 years old,
• fluent French speakers,
• healthy,
• without a beard at the time of testing,
• right-handed,
• being able to use both hands
• BMI between 18.5 and 30
• give written informed consen
• for women: contraception;

Критерии исключения

• neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
• pregnancy or breast-feeding
• under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
• not wanting to be informed of abnormalities detected during MRI scan,
• taking part in other studies with exclusion periods,
• MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Франция · 1 центр

• CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant — Bron

Идентификаторы

NCT: NCT07623746 · 69HCL25_1123 · 2025-A02658-41

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗