Correlation Analysis of Gene Characteristics of Malignant Tumors With Prognosis

Обзор

This study is a single-center observational investigation aimed at systematically exploring the key molecular features influencing the prognosis of malignant tumors by integrating multidimensional clinical information with multi-omics molecular data. The goal is to provide a critical scientific basis for constructing precise prognostic prediction models, identifying potential therapeutic targets, and optimizing clinical treatment strategies. The study plans to consecutively enroll adult patients with histologically confirmed malignant tumors who received antitumor therapy at our hospital between January 2017 and December 2025. Clinical data (including demographic characteristics, tumor pathology information, treatment histories, and survival follow-up data) will be systematically collected from electronic medical records. Additionally, tumor tissue or blood samples will be obtained from the patients for sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry analysis to comprehensively characterize the genomic features, immune microenvironment, and cellular heterogeneity of the tumors.

Вмешательства

• Препарат Immunotherapy Therapy
  Patients receiving immunotherapies such as immune checkpoint inhibitors. Immunotherapy can be administered as first-line or subsequent treatment, or as part of combination therapy, integrated with modalities such as surgery, chemotherapy, radiotherapy, and targeted therapy.
• Лучевая терапия Radiation Therapy
  Patients for whom radiotherapy is the primary or a significant component of their treatment. Radiotherapy may be administered with curative, adjuvant, or palliative intent, and can be given alone or in combination with surgery, chemotherapy, targeted therapy, immunotherapy, etc.
• Процедура Radical surgery
  Patients undergoing curative tumor resection as their primary treatment modality. Surgery may be performed with or without neoadjuvant/adjuvant chemotherapy, radiotherapy, targeted therapy, or immunotherapy.

Первичные конечные точки

• Overall Survival (OS) [Срок оценки: From date of treatment initiation until date of death or last follow-up, assessed up to 5 years.]

Вторичные конечные точки (3)

• Progression-Free Survival (PFS) [Срок оценки: From date of treatment initiation until date of progression or death, assessed up to 5 years.]
• Pathological Complete Response (pCR) [Срок оценки: At the time of surgery following neoadjuvant treatment, typically within 4-6 weeks after completion of therapy.]
• Major Pathologic Response (MRP) [Срок оценки: At the time of surgery following neoadjuvant treatment, typically within 4-6 weeks after completion of therapy.]

Критерии участия

Критерии включения

• Voluntarily sign the informed consent form.
• Treated at Nanfang Hospital, Southern Medical University between January 2017 and December 2025.
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2.
• Availability of surplus routinely discarded clinical tumor tissue samples (biopsy specimens or pathological sections) or blood samples for assays such as sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry.

Exclusion Criteria:Patients deemed by the investigator to be unsuitable for participation in this study.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Nanfang Hospital, Southern Medical University — Гуанчжоу

Публикации

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Идентификаторы

NCT: NCT07622667 · NFEC-2026-090

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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