Motion Sickness Severity and Sensorimotor Performance

Официальное название

The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study

Обзор

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Вмешательства

• Другое Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol
  Participants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol."

Первичные конечные точки

• Motion Sickness Severity (Graybiel Score) [Срок оценки: 1 hour]
• Static Balance [Срок оценки: 1 hour]
• Dynamic Balance Performance [Срок оценки: 1 hour]

Вторичные конечные точки (4)

• Knee Joint Proprioception [Срок оценки: 1 hour]
• Nine-Hole Peg Test (9HPT) Completion Time [Срок оценки: 1 hour]
• Tandem Walk Test Error Count [Срок оценки: 1 hour]
• Visual Reaction Time [Срок оценки: 1 hour]

Критерии участия

Критерии включения

• Individuals aged between 18 and 40 years.
• Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
• Normal hearing acuity.
• No history of acute or chronic vestibular disease, other than motion sickness.
• Normal or corrected-to-normal vision.
• Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

Критерии исключения

• Presence of any physical or orthopedic problem that could interfere with testing.
• History of acute or chronic instability, unsteadiness, or vertigo.
• Severe visual impairment.
• History of prior ear surgery.
• Presence of any neurological condition or disorder.
• History of migraines.
• Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
• Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07619469 · 25

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗