Validation of Population Characteristics and Dosage Prescriptions for Cognitive Function Intervention Benefits of Different Doses of Tai Chi in Elderly Patients With Mild Cognitive Impairment: A Real-World Cross-Sectional Study

Mild Cognitive Impairment (MCI) represents a critical early intervention window for delaying the onset and progression of dementia, and early non-pharmacological intervention has become an international consensus in this field. Our research team has completed two multicenter interventional randomized controlled trials (RCTs) pre-registered on ClinicalTrials.gov and their companion multicenter RCTs. Both studies adopted the standardized 24-form simplified Tai Chi as the intervention, with highly unified intervention procedures, movement specifications, and dose settings. These trials confirmed the dose-response relationship of Tai Chi intervention on cognitive improvement in older adults with MCI due to Alzheimer's disease, and preliminarily clarified the intervention effects of different Tai Chi dose combinations on patients' global cognition and cognitive subdomains.

On this basis, we will further identify the core characteristics of the population with significant cognitive benefits from Tai Chi intervention through machine learning algorithms. Based on data mining from 890 RCT participants, we will construct a dual-function machine learning prediction model for "beneficiary population identification + individualized Tai Chi dose prescription formulation". However, the above conclusions are all derived from standardized RCT settings, and their generalizability and clinical applicability in real-world community settings have not yet been validated.

As a sequential validation study, this research will conduct a cross-sectional survey by enrolling 150 older adults with long-term regular Tai Chi practice from communities in Fuzhou, China, to complete two-dimensional external validation of the previous RCT findings: to verify the consistency and feasibility between the beneficiary population characteristics and corresponding Tai Chi dose prescriptions mined from the parent RCTs, and the real Tai Chi dose combinations of the beneficiary population in the real world.

This study will form a closed loop from "causal evidence mining in RCTs" to "clinical application validation in real-world settings", and provide direct, high-level scientific evidence for the clinical promotion and individualized application of Tai Chi intervention in older adults with MCI.

• Wechsler Memory Scale [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Digital Symbol test [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Trial Making Test part B [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Stroop color word test [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Boston naming test [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Rey-Osterrieth complex graphics test [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]
• Rey Auditory Verbal Learning Test [Срок оценки: Single cross-sectional assessment at the time of study enrollment (baseline visit)]