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Набор скоро начнётся NCT07603206

Replacing Gas Stoves With Portable Electric Appliances to Improve Indoor Air Quality and Asthma Control

Без фазы С лечением Asthma Control

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Portable cooking appliances.
Кому может быть актуально
Состояния в реестре: Asthma Control. Базовые параметры: от 18 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Обзор

The goals of this study are to determine if replacing gas stoves with portable electric hot plates and electric toaster ovens will improve indoor air quality and asthma control. Researchers will enroll participants with poorly controlled asthma and provide them with hot plates and toaster ovens to use instead of gas stoves. Researchers will measure indoor air quality about 1-2 weeks before and about 2-3 months after providing portable appliances. Participants will answer questions about their asthma symptoms and take lung function tests about 1-2 weeks before and about 2-3 months after using portable appliances.

Подробное описание

Cooking on natural gas stoves is a major source of indoor air pollution and may contribute to asthma exacerbations. The investigators recently completed a single-arm trial in which gas stoves were replaced with electric induction stoves in the homes of 85 individuals with poorly controlled asthma. This led to 70% reductions in indoor NO2 levels and clinically important improvements in multiple measures of asthma control. Asthma Control Questionnaire scores improved by 1.1 points in this trial, which is twice as large as the average improvement seen with medical treatment such as inhaled corticosteroids and/or long-acting beta-agonists.

While these results are promising, the trial lacked a control group which limits the causal inferences that can be drawn. In addition, lung function was not directly measured. Moreover, the costs for stove installation and required electrical upgrades averaged nearly $10,000 per home. Most of this cost was related to the older housing stock of trial participants that often required upgrading the entire electrical panel in a house to install a new 240-volt kitchen outlet for the new electric stove. These costs can be a financial challenge for low-income households, limiting the scalability of a potentially effective solution for improving indoor air quality and asthma control.

To address these limitations, the investigators now propose a pilot randomized controlled trial using a delayed crossover design to evaluate the effectiveness of a low-cost intervention to improve indoor air quality, asthma control, and lung function. The investigators will leave gas stoves in place but will instruct participants to preferentially use two relatively inexpensive portable electric appliances that the investigators will provide. Cooking will be done with an electric induction hot plate and baking with an electric toaster oven. Induction hot plates use magnetic coils beneath a ceramic glass surface to send electromagnetic pulses directly to cookware. The investigators will provide induction stove compatible cookware because it is necessary to use cookware that has some steel or iron in order for the energy transfer to work.

The two portable electric appliances and induction cookware are estimated to cost approximately $600 in total and may provide a more affordable option for low-income households. If a household already has a microwave oven, they will be encouraged to use that as well. As the future scalability of the intervention will depend on its usage, the investigators will also evaluate usage and identify facilitators and barriers to consistent use of the portable devices.

Вмешательства

  • Другое Portable cooking appliances
    The investigators will leave gas stoves in place but will instruct participants to preferentially use two relatively inexpensive portable electric appliances that the investigators will provide. Cooking will be done with an electric induction hot plate and baking with an electric toaster oven.

Первичные конечные точки

  • Change in asthma control [Срок оценки: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.]
  • Change in indoor nitrogen dioxide levels [Срок оценки: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.]
Вторичные конечные точки (1)
  • Change in forced expiratory volume in 1 second (FEV1) [Срок оценки: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.]

Критерии участия

Критерии включения

  • Currently use gas stove for cooking or baking at least three times a week
  • Poorly controlled asthma as defined by an Asthma Control Questionnaire score of 1.5 or larger

Критерии исключения

  • Impaired decision making capacity
  • Pregnancy

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Рандомизированное
Модель
Перекрёстный дизайн
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

  • Bime C, Nguyen J, Wise RA. Measures of asthma control. Curr Opin Pulm Med. 2012 Jan;18(1):48-56. doi: 10.1097/MCP.0b013e32834db0f2. PMID 22081089
  • Audignon-Durand S, Ramalho O, Mandin C, Roudil A, Le Bihan O, Delva F, Lacourt A. Indoor exposure to ultrafine particles related to domestic activities: A systematic review and meta-analysis. Sci Total Environ. 2023 Dec 15;904:166947. doi: 10.1016/j.scitotenv.2023.166947. Epub 2023 Sep 9. PMID 37690752
  • Lebel ED, Finnegan CJ, Ouyang Z, Jackson RB. Methane and NOx Emissions from Natural Gas Stoves, Cooktops, and Ovens in Residential Homes. Environ Sci Technol. 2022 Feb 15;56(4):2529-2539. doi: 10.1021/acs.est.1c04707. Epub 2022 Jan 27. PMID 35081712

Идентификаторы

NCT: NCT07603206 · STUDY00001017

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗