Набор скоро начнётся NCT07599527

Megarectum in Adults

— Наблюдательное Idiopathic Megarectum

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Idiopathic megarectum group, Constipated patient group.
Кому может быть актуально: Состояния в реестре: Idiopathic Megarectum. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Официальное название

Megarectum in Adults: Congenital or Acquired Pathology?

Обзор

Severe functional constipation associated with a pathological increase in rectal volume, with or without colonic dilation, is known as megarectum. In the absence of an organic cause, megarectum is called idiopathic. This condition can begin at birth, in childhood, or in adulthood. The exact incidence of idiopathic megarectum (IM) is unknown, but it is considered a rare condition. Clinically, IM is usually considered in the context of chronic constipation that is refractory to traditional treatments and accompanied by rectal distension, abdominal pain, encopresis, and recurrent fecal impaction. The pathophysiological basis of IM remains poorly understood. A study using a rectal barostat-a device that measures rectal capacity and compliance (the rectum's ability to distend) by controlled distension of a rectal balloon-identified two distinct subgroups of patients with MI: (1) those with increased rectal compliance, who can be described as having "physiological" megarectum, in which marked rectal hyposensitivity-characterized by the absence of perception of rectal distension-and hypocontractility lead to chronic fecal accumulation and progressive overdistension due to loss of rectal elasticity; and (2) those with normal rectal compliance, who can be considered to have anatomical megarectum. It is not yet known whether these subgroups reflect different underlying etiologies. Furthermore, in patients with physiological megarectum, it is unclear whether the condition is primary or secondary to long-term rectal distension.

Подробное описание

The aim of this study is to identify and characterize elements of the clinical history, particularly early ones, associated with the disease, in order to contribute to the understanding of its pathophysiology.

To this end, the project aims to analyze the personal and family histories of patients with idiopathic bowel dysfunction (BD) and compare them with a population of constipated patients without BD, in order to determine the chronology of the onset of the condition (from birth, childhood/adolescence, or later) and to evaluate the risk factors for BD. It is also planned to describe the population of patients with BD to confirm whether or not different subgroups exist.

A better understanding of the pathophysiology of BD should make it possible to prevent the condition (if secondary to dyssynergia present in childhood) and/or to provide earlier, more appropriate management, thus avoiding acute episodes of bowel obstruction.

Вмешательства

Другое Idiopathic megarectum group
questionnaires documented by patients with suspected megarectum on anorectal manometry and confirmed by rectal barostat
Другое Constipated patient group
questionnaires completed by adult patients consulting for functional constipation without suspected megarectum on anorectal manometry

Первичные конечные точки

To determine if patients with Idiopathic MegaRectum (MI) have a history of earlier constipation in childhood than constipated patients without megarectum [Срок оценки: 1 day]
To determine if patients with Idiopathic MegaRectum (MI) have a history of more digestive symptoms in childhood than constipated patients without megarectum [Срок оценки: 1 day]

Вторичные конечные точки (12)

Comparison of environmental factors in constipated adults with MI and in constipated control subjects without megarectum [Срок оценки: 1 day]
Comparison of environmental factors in constipated adults with MI and in constipated control subjects without megarectum [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
megarectum phenotyping [Срок оценки: 1 day]
Constipation Severity Score Evaluation [Срок оценки: 1 day]
Constipation Severity Score Evaluation [Срок оценки: 1 day]
fecal incontinence severity score [Срок оценки: 1 day]

Критерии участия

Критерии включения

Idiopathic megarectum (IM) group:
Adult patients presenting with chronic constipation according to the Rome criteria;
Patients with megarectum suspected by anorectal manometry and confirmed by rectal barostat;
Isolated, idiopathic megarectum (no known cause);

Constipated group:

Constipated adult patients presenting consecutively with chronic functional constipation according to the Rome criteria;
Patients without megarectum suspected by anorectal manometry.