Идёт набор NCT07583186

Maternal Intake of Eggs and Infant Neurodevelopment

Без фазы С лечением Pregnancy Related

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Egg Supplementation, Healthy Prenatal Diet.
Кому может быть актуально: Состояния в реестре: Pregnancy Related. Базовые параметры: от 18 лет · Женщины.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

The fetal brain requires DHA, choline, lutein, and zeaxanthin (L/Z) for development, dependent on maternal intake during pregnancy. However, many pregnant women do not meet daily requirements through diet or prenatal vitamins. Egg yolks are rich in choline, and women who consume eggs daily are more likely to meet the adequate intake of 450 mg/day. A recent study by Christifano et al. found that maternal egg and neuroprotective nutrient intake predicted neurodevelopment at 32 and 36 weeks of gestation. This study aims to determine if fetal neurodevelopment is enhanced among women who consume a prenatal diet emphasizing egg consumption (EGG) versus a healthy prenatal diet education control group (HPD). Women between 12-20 weeks' gestation will be randomized into EGG and HPD groups. The EGG group will receive education on the importance of prenatal choline and egg consumption and be encouraged to consume 10-14 eggs per week. The HPD group will receive education on a healthy prenatal diet. Both groups will be encouraged to take a DHA supplement, and dietary intake of choline, L/Z, and DHA will be collected. Fetal heart rate variability will be measured at 36 weeks gestation and infant EEGs will be conducted postnatally to examine brain function. Increasing prenatal egg consumption is both economical and feasible to boost prenatal choline intake, promote offspring neurodevelopment, and guide prenatal dietary recommendations.

Вмешательства

Пищевая добавка Egg Supplementation
Encouraged to consume 10-14 eggs per week.
Пищевая добавка Healthy Prenatal Diet
Educated on standard healthy prenatal diet and encouraged to follow recommendations.

Первичные конечные точки

Fetal neurodevelopment as indexed by heart rate variability (HRV) [Срок оценки: 36 weeks gestational age]

Вторичные конечные точки (3)

Fetal neurodevelopment as indexed by heart rate variability (HRV) [Срок оценки: 36 weeks gestational age]
Infant neurodevelopment as indexed by event-related potentials (ERP) [Срок оценки: 1 month postnatal age]
Infant neurodevelopment as indexed by event-related potentials (ERP) [Срок оценки: 1 month postnatal age]

Критерии участия

Критерии включения

Pregnant females ≥18 years of age
12 to 20-weeks' gestation at enrollment
No serious illnesses likely to confound study outcomes
Consuming 3 eggs/week or less at enrollment and willing to increase consumption during the study
Singleton gestation
Available by telephone and text