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Идёт набор NCT07576920

Anxiety Levels in Living Liver Donors

— Наблюдательное Anxiety Postoperative

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Anxiety scores.
Кому может быть актуально
Состояния в реестре: Anxiety Postoperative. Базовые параметры: 18 лет — 65 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Turkey (Türkiye)
Следующий шаг
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Официальное название

Evaluation of Preoperative and Postoperative Anxiety in Living Liver Donors

Обзор

Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates. In adult patients undergoing various surgical procedures, preoperative anxiety rates have been reported to range from 11% to 80%. Most studies show that postoperative anxiety levels are related to preoperative anxiety levels. In patients undergoing general anesthesia, anxiety levels increase a few days after surgery as issues related to recovery and pain become apparent. Patients with high postoperative anxiety levels have also been reported to have a higher rate of medical complications.

Подробное описание

Liver transplantation is the only treatment for end-stage liver disease. The shortage of organ donations is leading clinicians to increasingly perform transplants from living donors. The biggest concern in living-donor liver transplantation is donor safety.

Liver donors undergo a major surgical operation that offers no medical benefit to them. The procedure can involve not only a physical but also a psychological burden. Given this situation, protecting both the physical and psychological health of liver donors is essential.

Anxiety studies primarily focus on organ transplant recipients However, the quality of life of donors and psychological conditions such as anxiety and depression are attracting increasing attention in the field of organ transplantation today. Neuropsychiatric Disease and Treatment 2018:14 1999-2005 A literature review revealed that there are limited studies investigating how donors are affected during the transplantation process in living-donor liver transplantation.

The aim of our study is to determine the preoperative and postoperative anxiety levels of donors in living donor liver transplantation and to identify possible conditions that may be associated with anxiety.

Вмешательства

  • Поведенческое Anxiety scores
    Anxiety scores will evaluated STAI test. The STAI test consists of two sections of 20 questions each. The first section of the test includes questions about how the person feels at that moment. Answers are given on a scale of 4 points. For example: I am calm right now: not at all=1, a little=2, a lot=3, completely=4. The second section of the test includes questions about how the person feels in general and is also answered on a scale of 4 points.

Первичные конечные точки

  • Anxiety Scores [Срок оценки: From 24 hours prior to the operation to postoperative 3. day and 7. day]
Вторичные конечные точки (2)
  • Presence of an alternative donor [Срок оценки: Prior to the operation]
  • Recipient Prognosis [Срок оценки: at the postoperative 3. day and 7. day]

Критерии участия

Критерии включения

  • ASA 1-2 group patients aged 18-65 years who are liver transplant donors

Критерии исключения

  • Patients with communication problems, those who are illiterate,
  • Patients do not have sufficient time for the tests,
  • Patients using sedatives, antidepressants, or antiepileptic drugs,
  • Patients with cerebrovascular or psychiatric diseases,
  • Patients with alcohol or substance addiction,
  • Patients who do not want or cannot undergo the second test

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Turkey (Türkiye) · 1 центр
  • Turgut Ozal Medical Center — Malatya

Публикации

  • Erdogan MA, Ucar M, Ozgul U, Erdogan S, Colak YZ, Ozhan O, Yaman R, Ugur Y, Aydemir S, Parlakpinar H. Preoperative and Postoperative Endogenous Melatonin and Anxiety Levels and Their Correlation in Living Liver Donors. Exp Clin Transplant. 2025 Apr;23(4):278-284. doi: 10.6002/ect.2021.0060. Epub 2021 Jul 16. PMID 34269646

Идентификаторы

NCT: NCT07576920 · Anxiety

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗