Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation

Официальное название

Socket Preservation and Odontogenic Graft Obtained From Human Tooth

Обзор

Tooth extraction triggers a cascade of biological events mediated by the local inflammatory response following surgical intervention and by the loss of masticatory stimulation to the periodontium. These factors disrupt the homeostasis and structural integrity of the periodontal tissues. Following tooth loss, bone remodeling is initiated and continues for several months, with the majority of dimensional and morphological changes occurring within the first three months. This early alveolar bone resorption may compromise future implant placement and prosthetic rehabilitation. Previous studies by Schmidt-Schultz and Schultz have demonstrated that biologically intact growth factors can be preserved within the collagenous extracellular matrix of ancient human bone and teeth. These findings suggest that stored dentin may retain biologically active growth factors and provide regenerative benefits comparable to those of freshly prepared dentin, while eliminating the need for simultaneous multiple surgical interventions. Moreover, the volume of particulate dentin exceeds twice the original root volume, allowing for the acquisition of sufficient graft material for clinical application. Based on these biological and volumetric advantages, the use of autogenous stored mineralized dentin grafts (ASMDG) has emerged as a promising approach for alveolar socket preservation. ASMDG may contribute to limiting post-extraction alveolar ridge resorption and maintaining ridge dimensions during the critical early healing period.

Первичные конечные точки

• Mean change in horizontal alveolar ridge width (mm) from baseline to 4 months (CBCT) [Срок оценки: Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)]

Вторичные конечные точки (1)

• Mean change in vertical alveolar ridge height (mm) from baseline to 4 months (CBCT) [Срок оценки: Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)]

Критерии участия

Критерии включения

• Patients requiring tooth extraction due to periodontal reasons (teeth with a hopeless prognosis), root caries, or root fractures, who are simultaneously candidates for posterior replacement with an osseointegrated implant, and who require extraction of at least two teeth.
• Integrity of the alveolar socket walls following tooth extraction.
• Patients who accept the study conditions, sign written informed consent, and agree to attend the scheduled follow-up visits.

Критерии исключения

• General contraindications for dental and/or surgical treatments.
• Inflammatory or autoimmune diseases of the oral cavity.
• Uncontrolled diabetes mellitus (HbA1c > 7%).
• History of malignancy requiring chemotherapy or radiotherapy within the past 5 years.
• Previous treatment with immunosuppressive agents, bisphosphonates, or high-dose corticosteroids.
• Smoking more than 10 cigarettes per day.
• Pregnant or breastfeeding women.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Turkey (Türkiye) · 1 центр

• Health Sciences University — Istanbul

Идентификаторы

NCT: NCT07573761 · 24/4

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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