Набор скоро начнётся NCT07573501

Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment

Без фазы С лечением Stroke Cognition Disorders

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: occupational therapy, real tACS, sham tACS.
Кому может быть актуально: Состояния в реестре: Stroke, Cognition Disorders. Базовые параметры: 30 лет — 80 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Китай
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with cognitive impairment after stroke, and to evaluate the safety of this protocol. The main purpose is to answer the following question: Can dual-site cross-frequency coupled tACS in the frontal parietal region improve the performance of working memory and cognitive-motor dual tasks in stroke patients? What is its mechanism of action? Researchers will compare the effects of real cross-frequency coupled stimuli and sham stimuli to see if the real stimuli can bring better results to patients. Participants will receive 40 minutes of real or sham electrical stimulation once a day for 5 consecutive days. Clinical evaluations (cognitive scales) and fNIRS were conducted respectively before and after stimulation to record the relevant brain activities at rest and during cognitive tasks

Вмешательства

Поведенческое occupational therapy
occupational therapy (especially cognitive therapy) 40min a day for 5 days
Другое real tACS
real theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy
Другое sham tACS
sham theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy

Первичные конечные точки

n-back task accuracy rate [Срок оценки: Baseline and 5-days]
n-back task reaction time [Срок оценки: Baseline and 5-days]
function connectivity during n-back task [Срок оценки: Baseline and 5-days]
Verbal fluency test（VFT）accuracy rate [Срок оценки: Baseline and 5-days]
Verbal fluency test（VFT）reaction time [Срок оценки: Baseline and 5-days]
function connectivity during Verbal fluency test（VFT） [Срок оценки: Baseline and 5-days]

Вторичные конечные точки (1)

Montreal Cognitive Assessment(MoCA) [Срок оценки: Baseline and 5-days]

Критерии участия

Критерии включения

Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
Age ranging from 30 to 80 years old;
Native language is Mandarin or Cantonese;
Right-handed;
Diagnosed with PSCI by the MoCA scale;
Able to cooperate in completing the speech repetition test;
Normal hearing.