Идёт набор NCT07573462

A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

Фаза III С лечением Pneumococcal Disease

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: PG4, 20-valent pneumococcal conjugate vaccine (20vPnC).
Кому может быть актуально: Состояния в реестре: Pneumococcal Disease. Базовые параметры: 42 Days — 98 Days · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США, Канада
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Официальное название

A PHASE 3, RANDOMIZED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY AND TOLERABILITY OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE IN HEALTHY INFANTS

Обзор

The purpose of this study is to learn about the safety of a new pneumococcal vaccine and how the new pneumococcal vaccine helps to fight against germs that can cause pneumonia (lung infections), meningitis (brain infections), and otitis media (ear infections) in infants when compared to the pneumococcal vaccine that is currently in use, 20vPnC (Prevnar 20®). This study will test if the new pneumococcal vaccine is as safe as the one that is currently in use. This new vaccine can possibly provide additional protection against germs that cause pneumococcal disease that are not included in the vaccines that are currently given to infants. Pneumococcal disease includes a variety of infections caused by a specific germ, Streptococcus pneumoniae. There are two groups in this study. All participants will be assigned to one of the two groups. This study is seeking participants who are: \- infants who are about 2 months of age About 2400 infants will be assigned by chance to one of the two groups to receive either PG4 (new vaccine) or 20vPnC (currently in use) into the left thigh muscle at 2, 4, 6, and 12 to 15 months of age. Infants will take part in this study for about 16 to 19 months (about 1 and a half years). During this time, infants will have 6 study clinic visits and 1 phone call. At these study clinic visits, parent(s)/legal guardian(s) will be asked if the infant experienced any side effects. A side effect is an unintentional or unexpected reaction to a vaccine.

Вмешательства

Биопрепарат PG4
Multivalent Pneumococcal Vaccine
Биопрепарат 20-valent pneumococcal conjugate vaccine (20vPnC)
20-valent pneumococcal conjugate vaccine (20vPnC)

Первичные конечные точки

Percentage of participants reporting local reactions within 7 days after each dose [Срок оценки: Day 7]
Percentage of participants reporting systemic events within 7 days after each dose [Срок оценки: Day 7]
Percentage of participants reporting adverse events (AEs) from Dose 1 to 1 month after Dose 3 [Срок оценки: Dose 1 to 1 month after Dose 3]
Percentage of participants reporting AEs from Dose 4 to 1 month after Dose 4 [Срок оценки: Dose 4 to 1 month after Dose 4]
Percentage of participants reporting serious adverse events (SAEs) [Срок оценки: Dose 1 to 6 months after Dose 4]

Критерии участия

Критерии включения

Infants who are about 2 months of age
Healthy infants determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study.

Критерии исключения

History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis).
Major known congenital malformation or serious chronic disorder.
Other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
Previous vaccination with any licensed or investigational pneumococcal vaccine, or planned receipt through study participation.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да