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Идёт набор NCT07566832

Velocity-Based Resistance Training Effects on Inflammation in Older Adults

Без фазы С лечением Aging Inflammatory Response

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Resistance exercise.
Кому может быть актуально
Состояния в реестре: Aging, Inflammatory Response. Базовые параметры: 60 лет — 75 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Тайвань
Следующий шаг
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Официальное название

Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults

Обзор

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

Вмешательства

  • Другое Resistance exercise
    The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.

Первичные конечные точки

  • Changes in IL-6 concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in soluble IL-6 receptor concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in soluble gp130 concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in IL-10 concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in IL-1RA concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in TNF-α concentration [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
Вторичные конечные точки (12)
  • Borgs Ratings of Perceived Exertion (RPE) [Срок оценки: 1-hour during each exercise intervention]
  • Handgrip strength [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Knee extension strength [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • 30-second chair-stand test [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Single-leg balance test [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Timed up and go test [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in SHIP1 protein expression in peripheral blood mononuclear cells (PBMCs) [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in gp130 (CD130) protein expression in PBMCs [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in STAT3 protein expression in PBMCs [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in phosphorylated STAT3 protein expression in PBMCs [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in IL-6 receptor alpha (CD126) protein expression in PBMCs [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]
  • Changes in Beta-2 adrenergic receptor (β2-AR) protein expression in PBMCs [Срок оценки: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining]

Критерии участия

Критерии включения

  • Aged 60-75 years or older
  • No regular resistance training habit (defined as ≥2 sessions per week) in the past year
  • No musculoskeletal injuries within the past six months

Критерии исключения

  • Obesity (BMI > 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
  • Regular use of anti-inflammatory medications (e.g., NSAIDs).
  • Smoking or alcohol abuse
  • Inability to safely perform the prescribed resistance exercise movements
  • Unable to fully comprehend the study information and instructions.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Перекрёстный дизайн
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Тайвань · 1 центр
  • National Taiwan Normal University — Taipei

Идентификаторы

NCT: NCT07566832 · ECKIRB1140803

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗