Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)

Обзор

Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.

Подробное описание

An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (\>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.

Вмешательства

• Диагностический тест Laser Speckle Contrast Imaging
  Investigation of Systemic Endothelial Microvascular Function
• Диагностический тест Handgrip Dynamometry (Muscle Strength)
  Serving as a marker of systemic muscle strength and sarcopenia.
• Диагностический тест Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)
  This test will assess the strength and power of the lower limbs.
• Диагностический тест Single-Leg Balance Test
  Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
• Диагностический тест Assessment of Global Cognitive Function
  Overall cognitive function will be assessed using the Mini-Mental State Examination.

Первичные конечные точки

• Systemic (cutaneous) microcirculatory reactivity. [Срок оценки: up to 20 minutes]

Вторичные конечные точки (1)

• Muscle Strength [Срок оценки: up to 10 minutes]

Критерии участия

Критерии включения

• Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
• Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.

Критерии исключения

• Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
• Smoking: Active or quit less than 5 years ago.
• Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
• Surgery or trauma in the last 60 days.
• Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
• Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Бразилия · 1 центр

• Eduardo Tibiriçá — Rio de Janeiro

Идентификаторы

NCT: NCT07563725 · VAMP-Aging

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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