Barrier Functions oF Skin in ICU: SKIN-BAR

Pressure injuries (PIs) remain a major complication in intensive care units (ICUs), associated with increased morbidity, mortality, and healthcare costs. Early detection and prevention are critical; however, current assessment methods rely largely on subjective clinical evaluation and risk scales, which may lack sensitivity in detecting subclinical skin barrier impairment.

Recent advances in biosensor technology enable objective, non-invasive assessment of skin barrier function through biophysical parameters such as transepidermal water loss (TEWL), skin pH, stratum corneum hydration, local temperature, and sebum levels. These parameters reflect epidermal integrity and may provide early indicators of pressure-induced tissue damage before visible clinical signs emerge.

The SKIN-BAR study is designed as a prospective, longitudinal cohort study conducted in ICU patients. The primary objective is to evaluate skin barrier function in pressure injury-prone anatomical regions and to identify factors influencing these parameters. Specifically, the study aims to:

1. assess temporal changes in biophysical skin parameters, 2. examine relationships between these parameters, 3. compare measurements between pressure injury-developing and non-developing patients, and 4. identify clinical and demographic factors associated with impaired skin barrier function.

Data will be collected using validated, non-invasive biosensor devices. Measurements will be performed at multiple time points (including early ICU admission and follow-up intervals) and across multiple anatomical sites, including the sacrum, trochanters, scapulae, lateral legs, and posterior neck. Control measurements from adjacent intact skin will also be obtained.

A comprehensive dataset including clinical, demographic, and physiological variables will be analyzed to determine predictors of pressure injury development and to better understand the pathophysiological mechanisms underlying skin barrier disruption in critically ill patients.

This study is expected to contribute to the development of objective, evidence-based approaches for early detection and prevention of pressure injuries in ICU settings and to support the integration of biosensor technologies into clinical care protocols.

• Change in skin surface pH in pressure injury-prone anatomical regions [Срок оценки: From ICU admission (within the first 4 hours), 24 hours, 48 hours, 96 hours, day 13.]
• Change in local skin temperature in pressure injury-prone anatomical regions [Срок оценки: From ICU admission (within the first 4 hours), 24 hours, 48 hours, 96 hours, day 13.]
• Incidence of pressure injury during ICU stay [Срок оценки: Daily from baseline through Day 13 (or until ICU discharge, whichever occurs first)]