Effect of Neurodynamic Mobilization of Vagus Nerve on Irritable Bowel Syndrome in Women

Обзор

goal of this interventional study to investigate the effect of neurodynamic mobilization of vagus nerve on irritable bowel syndrome in women. The main question it aims to answer is: is there an effect of neurodynamic mobilization of the vagus nerve on irritable bowel syndrome? The intervention will include neurodynamic mobilization of vagus nerve sessions ,Participants will receive the treatment for 6 week. Assessment will be done before and after treatment.

Подробное описание

IBS is a chronic functional gastrointestinal disorder that profoundly affects patients' quality of life (QOL). Among the various symptoms, abdominal pain was the most commonly reported and often perceived as the most debilitating. Some patients, particularly mothers, even described it as more intense than labor pain. This pain led to a range of negative consequences, including impaired concentration, sleep disturbances, episodes of fainting, vomiting, physical immobility, inability to work, and feelings of depression .Neural mobilization promotes improved mobility and interaction between nerves and adjacent tissues (interfaces) through the application of manual techniques or specific exercises .Neurodynamic techniques targeting the vagus nerve have shown potential as an effective approach to promote parasympathetic nervous system activation. The application of vagus nerve neurodynamic techniques was associated with a significant reduction in mean heart rate (HR), suggesting a positive modulatory effect on parasympathetic nervous system activity .The potential therapeutic role of vagus nerve neurodynamic mobilization in managing IBS has not been extensively explored in the literature.

Therefore, this study aims to investigate the effectiveness of neurodynamic techniques targeting the vagus nerve in alleviating symptoms and improving quality of life in patients with IBS.

Вмешательства

• Поведенческое neurodynamic mobilization of vagus nerve
  To target the intracranial portion of the vagus nerve, upper cervical flexion combined with contralateral lateral flexion was utilized, while ipsilateral cervical rotation was employed to load the cervical portion of the nerve. The neurodynamic intervention involved passive movements applied to the cervical spine, including rotation toward the side of the vagus nerve being treated, lateral flexion to the opposite side, and flexion. different medications seem to help with various IBS complaints.
• Поведенческое Standard care
  Dietary advice as : 1. Eating meals at the same time each day with regular intervals. 2. Avoid eating too little or too much. 3. Staying well-hydrated. 4. Cutting down on processed, fatty, and spicy foods. 5. It is advisable to limit caffeine, carbonated drinks, and alcohol. 6. Start with small amounts of soluble fiber and gradually increase it to improve tolerance. 7. Avoid insoluble fibers, gas-producing foods like beans, and artificial sweeteners. 8. Being aware of and avoiding foods that ca

Первичные конечные точки

• Symptom severity in patients with Irritable Bowel Syndrome [Срок оценки: 6 weeks]

Вторичные конечные точки (2)

• Quality of life in patients with Irritable Bowel Syndrome [Срок оценки: 6 weeks]
• Anxiety and depression levels in patients with Irritable Bowel Syndrome [Срок оценки: 6 weeks]

Критерии участия

Критерии включения

• 32 Females with mild to moderate IBS ,were recruited for this study by referral from a physician.
• aged 20-45 (i.e., the most common age for developing IBS)
• Patients must experience abdominal pain recurring at least once weekly over the past three months.
• This pain must be linked to two or more of the following features: occurring in relation to defecation, accompanied by a change in stool frequency, or accompanied by a change in stool form or appearance.
• Symptoms should have been present during the last three months, with onset at least six months before diagnosis.

Критерии исключения

Subjects will be excluded if they have:

• Organic gastrointestinal disorders.
• Thyroid abnormalities.
• Coexisting cardiovascular, respiratory, renal, or hepatic conditions.
• Pregnancy.
• Blood disorders. (e.g., hemophilia, coagulation disorders, leukemia, thalassemia, sickle cell disease).
• Neurological or musculoskeletal conditions affecting muscle tone.
• Psychiatric illnesses ( patients with depression in the absence of IBS).
• Fibromyalgia.
• A history of gastrointestinal surgery or resection, , or other chronic diseases associated with gastrointestinal issues such as inflammatory bowel disease, ulcers, or cancer.
• A history of alcohol or drug abuse, abdominal surgery within the past six months.
• Recent cervical or cardiac surgery, or recent major trauma.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Египет · 1 центр

• Faculty of physical therapy — Giza

Идентификаторы

NCT: NCT07560345 · P.T.REC/012/006238

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗