Intermittent Walking Training and Cardiometabolic Health in Premenopausal and Postmenopausal Women

Официальное название

Effects of a 10-Week Moderate-Intensity Intermittent Walking Training Program on Aerobic Capacity, Cardiometabolic Risk Factors, and Inflammatory Markers in Premenopausal and Postmenopausal Women

Обзор

The goal of this clinical trial is to compare premenopausal and postmenopausal women regarding the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity and selected cardiometabolic and inflammatory markers. The main question it aims to answer is: Does a MIWT program induce differential improvements in aerobic capacity, body composition, lipid profile, and inflammatory markers between premenopausal and postmenopausal women? Participants in the premenopausal group will perform a 10-week MIWT program, three sessions per week. Participants in the postmenopausal group will perform the same 10-week MIWT program, three sessions per week. Each training session consists of 5 repetitions of 6-minute walking (6MWT) at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity (6-minute walk test), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) will be assessed before and after the intervention in both groups.

Подробное описание

In premenopausal and postmenopausal women, differences in cardiometabolic profile, body composition, and aerobic capacity are commonly observed, with postmenopausal women generally presenting higher cardiometabolic risk. Regular physical activity is known to improve these parameters; however, the specific effects of moderate-intensity intermittent walking training (MIWT) on the comparison between premenopausal and postmenopausal women remain insufficiently explored.

The purpose of this study is to compare the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity, body composition, cardiometabolic risk factors, and inflammatory markers in premenopausal and postmenopausal women.

Thirty-two women were allocated into a premenopausal group (n = 16) and a postmenopausal group (n = 16). Both groups performed a MIWT program three times per week for 10 weeks. Each training session consisted of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions.

Body composition, aerobic capacity (6MWT), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) were assessed before and after the intervention in both groups to evaluate changes induced by the training program.

Вмешательства

• Поведенческое Moderate-Intensity Intermittent Walking Training (MIWT)
  Participants will perform a 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. The same intervention is applied to both premenopausal and postmenopausal women.

Первичные конечные точки

• Body Mass Index (BMI) [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Body Fat Percentage [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Waist Circumference [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Hip Circumference [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• C-Reactive Protein (CRP) [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Total Cholesterol [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• High-Density Lipoprotein (HDL) Cholesterol [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Low-Density Lipoprotein (LDL) Cholesterol [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Triglycerides [Срок оценки: Baseline and after the 10 weeks of the training intervention.]

Вторичные конечные точки (3)

• 6-Minute Walk Test (6MWT) Distance [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Blood Pressure (Systolic and Diastolic) [Срок оценки: Baseline and after the 10 weeks of the training intervention.]
• Resting Heart Rate [Срок оценки: Baseline and after the 10 weeks of the training intervention.]

Критерии участия

Критерии включения

• Women aged 32 to 43 years (premenopausal, with regular menstrual cycles for at least 12 months) or 49 to 65 years (postmenopausal, with absence of menstruation for at least 12 months).

Body mass index (BMI) > 24.9 kg/m².

• For the postmenopausal group: amenorrhea ≥ 12 months.
• For the premenopausal group: regular menstrual cycles for at least 12 months.

Критерии исключения

• Cardiovascular diseases (hypertension, heart failure).
• Presence of metabolic or inflammatory disorders (e.g., uncontrolled diabetes, autoimmune diseases, active infections).

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

Tunisia · 1 центр

• High Institute of Sport and Physical Education of Kef, University of Jendouba — El Kef

Идентификаторы

NCT: NCT07555457 · IW-CardioWomen-2026

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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