Набор скоро начнётся NCT07546994

Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters

— Наблюдательное Catheter-Related Infections Biofilms Infection Prevention

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Microbial analysis of catheter biofilm.
Кому может быть актуально: Состояния в реестре: Catheter-Related Infections, Biofilms, Infection Prevention. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies. The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.

Вмешательства

Другое Microbial analysis of catheter biofilm
Identification and sampling of the catheter, standard microbiological analysis, inclusion and transfer (INSERM platform), biofilm analysis, and collection of associated data (clinical, biological and related to the catheter).

Первичные конечные точки

Concentration (density) of viable bacterial biofilm [Срок оценки: Baseline]

Вторичные конечные точки (3)

Provide a descriptive analysis of the population of colonized or infected central venous catheters, including clinical, biological, and microbiological data. [Срок оценки: Baseline]
Evaluate correlation between biofilm density and the following factors: microbiological, catheter-related, clinical, and patient-related. [Срок оценки: Baseline]
Evaluate correlation between the preferred location of biofilm and the following factors: microbiological, catheter-related, clinical, and patient-related. [Срок оценки: Baseline]

Критерии участия

Критерии включения

Central venous catheters (conventional central venous lines, dialysis catheters, PICC lines) showing positive microbiological culture taken from adult patients in the critical care units (intensive care units, post-operative intensive care units and post-resuscitation intensive care units)
Patient consent is free, informed, and non-opposition, provided after delivery of an information letter and oral explanation.