Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels

Официальное название

Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels: A Double-Blind, Randomized, Placebo-Controlled Trial

Обзор

This study is a double-blind, randomized, placebo-controlled trial designed to examine whether 8 weeks of Cistanche deserticola supplementation, when combined with a standardized anaerobic training program, can improve anaerobic exercise performance, recovery, and selected body composition outcomes in young adult men with different athletic training levels. Participants will be assigned to receive either Cistanche deserticola extract or a matched placebo while completing the same supervised anaerobic training program. The study will assess changes in anaerobic performance, including Wingate test outcomes and jump performance, as well as recovery-related indicators such as blood lactate, creatine kinase, malondialdehyde, testosterone, cortisol, and the testosterone-to-cortisol ratio. Body composition outcomes, including body fat percentage and skeletal muscle mass, will also be evaluated. The purpose of this study is to determine whether Cistanche deserticola supplementation provides additional benefits beyond training alone, and whether these effects differ between highly trained and recreationally trained participants.

Вмешательства

• Пищевая добавка Cistanche deserticola
  Participants receive Cistanche deserticola extract paste at a dose of 5 g/day for 8 weeks. The supplement is administered in two sachets per day, one after breakfast and one after lunch. The product is derived from Cistanche deserticola Y.C. Ma cultivated in Inner Mongolia and consists primarily of phenylethanoid glycosides. Batch-specific quality-control documentation is provided by the supplier to ensure consistency.
• Пищевая добавка Matched placebo paste
  Participants receive a matched placebo for 8 weeks. The placebo is administered in two sachets per day, one after breakfast and one after lunch, following the same schedule as the experimental supplement. It contains maltodextrin, microcrystalline cellulose, caramel coloring, and a food-grade bittering agent, and is matched to the active supplement in appearance, weight, texture, and taste.
• Поведенческое Standardized anaerobic training program
  All participants complete the same supervised standardized anaerobic training program 3 times per week for 8 consecutive weeks. Each session lasts approximately 50 to 65 minutes and includes a dynamic warm-up, repeated sprint training, explosive/strength-support exercises, short-bout high-intensity interval training, and a cool-down. Training load is progressively increased across the intervention period, and attendance as well as session rating of perceived exertion are recorded throughout the

Первичные конечные точки

• Peak power during the 30-second Wingate Anaerobic Test [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Squat jump height [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Countermovement jump [Срок оценки: Baseline (week 0) and post-intervention (week 8)]

Вторичные конечные точки (10)

• Average power during the 30-second Wingate Anaerobic Test [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Minimum power during the 30-second Wingate Anaerobic Test [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Power drop during the 30-second Wingate Anaerobic Test [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Post-exercise blood lactate response [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Serum creatine kinase concentration [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Serum malondialdehyde concentration [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Serum testosterone concentration [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Body fat percentage [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Skeletal muscle mass [Срок оценки: Baseline (week 0) and post-intervention (week 8)]
• Serum cortisol concentration [Срок оценки: Baseline (week 0) and post-intervention (week 8)]

Критерии участия

Критерии включения

• Male, aged 18 to 25 years
• Body mass index (BMI) between 18.5 and 25.0 kg/m²
• Able and willing to provide written informed consent
• Willing to comply with study procedures, supplementation, training, and assessments
• Belonging to one of the following athletic training strata:
• High-level elite stratum: Chinese National Level-1 Athlete standard in sprint-related events, regular training in past 12 months and active during study
• Amateur stratum: regular exercise-training background in past 12 months without National Level-1 status

Критерии исключения

• Use of steroids or ergogenic supplements during study
• Known cardiovascular, metabolic, musculoskeletal, or other conditions making participation unsafe or affecting outcomes
• Current use of medications affecting muscle growth, recovery, hormones, or high-intensity performance
• Current injury or limitation preventing safe participation
• Known allergy or intolerance to supplement/placebo ingredients
• Participation in another clinical trial or structured intervention during study period
• Inability or unwillingness to comply with protocol
• Any other condition deemed unsuitable by investigators

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Организация здравоохранения

Центры проведения

Китай · 1 центр

• Wuhan Sport University — Ухань

Публикации

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• Oliver JL, Ramachandran AK, Singh U, Ramirez-Campillo R, Lloyd RS. The Effects of Strength, Plyometric and Combined Training on Strength, Power and Speed Characteristics in High-Level, Highly Trained Male Youth Soccer Players: A Systematic Review and Meta-Analysis. Sports Med. 2024 Mar;54(3):623-643. doi: 10.1007/s40279-023-01944-8. Epub 2023 Oct 28. PMID 37897637
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Идентификаторы

NCT: NCT07546513 · 2025161

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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