Physical Functions and Lifestyle Behaviours in Post-COVID-19 Syndrome Based on Circadian Rhythms

Официальное название

Comparison of Respiratory Muscle Strength, Physical Activity Level, and Dietary Habits in Individuals With Post-COVID-19 Syndrome Having Different Circadian Rhythms

Обзор

Post-COVID-19 syndrome is associated with persistent symptoms such as fatigue, reduced physical activity, and impaired respiratory function. Circadian rhythm differences (chronotype) may influence lifestyle behaviors including physical activity, nutrition, and sleep patterns. This observational cross-sectional study aims to compare respiratory muscle strength, physical activity levels, and nutritional habits among individuals with post-COVID-19 syndrome according to their chronotype (morning, intermediate, and evening types). Additionally, genetic analysis of the CLOCK gene polymorphism will be performed to support objective evaluation of circadian rhythm differences. The findings of this study may help to better understand the role of circadian rhythm in post-COVID-19 syndrome and contribute to the development of individualized rehabilitation and lifestyle interventions.

Подробное описание

Post-COVID-19 syndrome is characterized by persistent symptoms such as fatigue, reduced exercise tolerance, and impaired respiratory function following acute SARS-CoV-2 infection. Emerging evidence suggests that circadian rhythm disruption may play a role in the pathophysiology of these symptoms by affecting metabolic regulation, hormonal balance, sleep quality, and physical performance.

Circadian rhythm varies between individuals and is commonly classified into chronotypes as morning, intermediate, and evening types. These chronotypes are associated with differences in daily activity patterns, nutritional behaviors, and physiological performance.

The aim of this observational cross-sectional study is to compare respiratory muscle strength, physical activity levels, nutritional habits, sleep quality, fatigue perception, and gastrointestinal symptoms in individuals with post-COVID-19 syndrome according to their chronotype.

Participants aged 18-65 years with a confirmed diagnosis of post-COVID-19 syndrome will be included. Chronotype will be assessed using the Munich Chronotype Questionnaire (MCTQ). Respiratory muscle strength will be evaluated using maximal inspiratory and expiratory pressures (MIP/MEP), and dynamic respiratory parameters will be assessed using a POWERbreathe device. Respiratory muscle endurance will be measured using threshold loading protocols.

Physical activity levels will be assessed using the International Physical Activity Questionnaire (IPAQ), while nutritional intake will be evaluated using 24-hour dietary recall. Sleep quality, fatigue severity, and gastrointestinal symptoms will be assessed using validated questionnaires.

In addition, blood samples will be collected for genetic analysis of the CLOCK gene polymorphism (rs1801260) using PCR-RFLP techniques to provide an objective assessment of circadian rhythm differences.

This study is expected to provide comprehensive insight into the relationship between circadian rhythm and functional, behavioral, and physiological outcomes in post-COVID-19 syndrome, and may contribute to the development of individualized rehabilitation strategies.

Первичные конечные точки

• Respiratory Muscle Strength [Срок оценки: Time Frame: Day 1]
• Dynamic respiratory muscle strength [Срок оценки: Time Frame: Day 1]
• Respiratory muscle endurance [Срок оценки: Time Frame: Day 1]

Вторичные конечные точки (7)

• Physical Activity Level [Срок оценки: Time Frame: Day 1]
• Dietary Intake [Срок оценки: Time Frame: Day 1]
• Chronotype Classification [Срок оценки: Time Frame: Day 1]
• Fatigue Severity [Срок оценки: Time Frame: Day 1]
• Gastrointestinal Symptoms [Срок оценки: Time Frame: Day 1]
• Sleep Quality [Срок оценки: Time Frame: Day 1]
• Classificationof human faeces forms [Срок оценки: Time Frame: Day 1]

Критерии участия

Критерии включения

• Diagnosed with Post-COVID-19 Syndrome
• Aged between 18-65 years
• Able to read and understand Turkish
• Voluntary participation
• Classified as Post-Covid Functional Status Scale (PCFS) grade 2-3
• Clinically stable condition
• No uncontrolled comorbidities (e.g., hypertension, diabetes under control)
• No orthopedic or neurological conditions affecting exercise testing

Критерии исключения

• Recent myocardial infarction or pulmonary embolism
• Severe uncontrolled chronic diseases
• Neurological or orthopedic conditions limiting mobility
• Psychiatric or neurological disorders affecting cooperation or test compliance
• Inability to complete assessments

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Другое

Центры проведения

Turkey (Türkiye) · 1 центр

• Hacettepe University Faculty of Physical Therapy and Rehabilitation — Ankara

Публикации

• Suwazono Y, Dochi M, Sakata K, Okubo Y, Oishi M, Tanaka K, Kobayashi E, Kido T, Nogawa K. A longitudinal study on the effect of shift work on weight gain in male Japanese workers. Obesity (Silver Spring). 2008 Aug;16(8):1887-93. doi: 10.1038/oby.2008.298. Epub 2008 Jun 5. PMID 18535539
• Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A. Circadian Rhythm and the Gut Microbiome. Int Rev Neurobiol. 2016;131:193-205. doi: 10.1016/bs.irn.2016.07.002. Epub 2016 Sep 6. PMID 27793218

Идентификаторы

NCT: NCT07545499 · FTREK25/33

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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