Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth

Официальное название

Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth (A Case Series Study).

Обзор

This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices. Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth. In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period. The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.

Подробное описание

Tooth autotransplantation is a well-established treatment modality for replacing missing teeth, particularly in young patients. However, the success of this procedure depends on multiple biological factors, including the preservation of the periodontal ligament, prevention of root resorption, and the potential for pulpal healing. In teeth with closed apices, pulpal revascularization is limited, which may negatively affect the long-term prognosis of the transplanted tooth.

Recently, platelet concentrates have gained increasing attention in regenerative dentistry due to their ability to enhance wound healing and tissue regeneration. Concentrated Growth Factors (CGF) represent an advanced generation of autologous platelet concentrates characterized by a dense fibrin matrix rich in growth factors such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF). These biological mediators play a critical role in angiogenesis, cell proliferation, and tissue regeneration.

The present study is designed to evaluate the clinical and radiographic outcomes of using CGF in autotransplantation of teeth with closed apices. The hypothesis is that the application of CGF at the recipient site may enhance healing, improve periodontal ligament regeneration, and reduce the incidence of complications such as inflammatory or replacement root resorption.

Eligible patients requiring tooth autotransplantation will be recruited according to predefined inclusion and exclusion criteria. The surgical procedure will be performed following standard protocols, with careful atraumatic extraction of the donor tooth and proper preparation of the recipient socket. CGF will be prepared from the patient's own blood using a standardized centrifugation protocol and applied to the recipient site prior to transplantation.

Postoperative follow-up will be conducted at specific intervals to assess both clinical and radiographic outcomes. Clinical evaluation will include parameters such as tooth mobility, periodontal probing depth, gingival condition, pain, and presence of infection or ankylosis. Radiographic assessment will include evaluation of bone healing, periodontal ligament space, root resorption (inflammatory or replacement), and periapical status.

Data will be collected and analyzed to compare outcomes and determine the effectiveness of CGF in improving the success rate of autotransplanted closed apex teeth. The results of this study may contribute to establishing evidence-based protocols for enhancing regenerative outcomes in tooth autotransplantation procedures.

Вмешательства

• Процедура closed apex teeth auto transplantation
  In this study, autotransplantation of teeth with closed apices will be performed following standard surgical protocols. The donor tooth will be atraumatically extracted with maximum preservation of the periodontal ligament, and the recipient socket will be carefully prepared to receive the transplanted tooth. In the intervention group, Concentrated Growth Factors (CGF) will be prepared from the patient's venous blood using a standardized centrifugation protocol. The obtained CGF will be applied

Первичные конечные точки

• Changes in Radiographic Bone Density at the Recipient Site [Срок оценки: 6 months]

Критерии участия

Критерии включения

• Donor Tooth : any 3rd molar tooth with fully developed roots (confirmed radiographically) and not functionally used (semi impacted, impacted but easily to be extracted, absence of the opposing etc…) .
• Recipient Site : Recipient 1st or 2nd molar region (either upper or lower) with adequate bone volume to receive the auto transplanted tooth.
• Oral Health: Good general oral hygiene and absence of active periodontal disease.
• Systemic Health: patients with no contraindications for minor oral surgery.

Критерии исключения

• Poor Oral Hygiene: Presence of uncontrolled gingivitis or periodontitis.
• Systemic Conditions: Patients with systemic diseases that may impair healing (e.g., uncontrolled diabetes, immunosuppression, bleeding disorders or bone metabolic diseases ).
• Smoking: Active smokers or tobacco users.
• Pregnancy or Lactation: Female patients who are pregnant or breastfeeding

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Другое

Центры проведения

Египет · 1 центр

• Faculty of oral and dental surgery cairo university — Cairo

Публикации

• Keranmu D, Ainiwaer A, Nuermuhanmode N, Ling W. Application of concentrated growth factor to autotransplantation with inflammation in recipient area. BMC Oral Health. 2021 Oct 30;21(1):556. doi: 10.1186/s12903-021-01915-3. PMID 34717618
• Czochrowska EM, Stenvik A, Bjercke B, Zachrisson BU. Outcome of tooth transplantation: survival and success rates 17-41 years posttreatment. Am J Orthod Dentofacial Orthop. 2002 Feb;121(2):110-9; quiz 193. doi: 10.1067/mod.2002.119979. PMID 11840123
• Chen J, Wan Y, Lin Y, Jiang H. Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine. J Craniofac Surg. 2021 Jun 1;32(4):1316-1321. doi: 10.1097/SCS.0000000000007182. PMID 33055562

Идентификаторы

NCT: NCT07538921 · CU-OMFS-CGF-AT-01-2026

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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