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Идёт набор NCT07525583

Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore

— Наблюдательное Frailty Intrinsic Capacity Lifestyle

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway).
Кому может быть актуально
Состояния в реестре: Frailty, Intrinsic Capacity, Lifestyle. Базовые параметры: от 60 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Сингапур
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore. Using the World Health Organization (WHO) Integrated Care for Older People (ICOPE) framework and digital screening tools, participants will undergo IC domain screening in community settings. Individuals identified with early decline will receive targeted multidomain interventions and/or referral to primary or specialist care as indicated. Participants will be followed longitudinally to assess feasibility, uptake, functional trajectories, and implementation outcomes.

Подробное описание

Population ageing is associated with progressive decline in intrinsic capacity (IC), defined by WHO as the composite of physical and mental capacities across mobility, cognition, vitality (nutrition), psychological, and sensory domains. Early detection of IC decline enables preventive, person-centred interventions to delay frailty, disability, and long-term care dependency.

The SPICE study operationalises the WHO ICOPE framework within Singapore's community ageing ecosystem through a coordinated hub-and-spoke model linking:Community screening platforms (e.g., Active Ageing Centres), Community Health Posts, Regional health system services and other social service organisations.

The pathway consists of:

Step 1: IC Screening

* Screening using WHO ICOPE Monitor tools. Step 2: In-Depth Assessment * Participants screening positive for decline undergo structured assessment of affected domains.

Step 3: Risk Stratification \& Care Planning

* Traffic-light classification (low, moderate, high risk) with personalised care plans.

Step 4: Intervention \& Referral

* Multidomain community interventions (exercise, nutrition, cognitive stimulation, psychosocial engagement) or escalation to medical services when required.

Step 5: Monitoring \& Follow-up

* Longitudinal follow-up with repeat IC assessments at defined intervals. The study will evaluate implementation feasibility, prevalence of IC decline, adherence to care pathways, functional outcomes, and cost-effectiveness within a real-world community system.

In addition, blood and digital biomarkers will be collected from a subgroup of study participants.

Вмешательства

  • Другое ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway)
    Participants will undergo baseline intrinsic capacity (IC) screening using WHO ICOPE-aligned tools in community settings. Follow-up contacts/visits will occur over the study period and include: 1. Scheduled follow-up at predefined intervals (e.g., every 3, 6-12 months) for repeat IC assessment and outcome data collection; and 2. Triggered (non-scheduled) follow-up that is initiated when remote/digital monitoring indicates decline in one or more IC domains, poor adherence, or when major intercur

Первичные конечные точки

  • Prevalence of intrinsic capacity decline at baseline (robust / pre-frail) [Срок оценки: Baseline]
  • Uptake of recommended actions (implementation effectiveness) [Срок оценки: Up to 3 months post-recommendation]
Вторичные конечные точки (7)
  • Identification of (a set of) biomarkers of aging [Срок оценки: 30 months]
  • Feasibility and reach [Срок оценки: 30 months]
  • Change in intrinsic capacity and function over time [Срок оценки: 12 months from enrolment]
  • Frailty progression [Срок оценки: over 12 months follow up]
  • Cost per participant screened [Срок оценки: 3 years]
  • Number of participants with at least one unscheduled emergency department visit or hospital admission [Срок оценки: 12 months]
  • Implementation outcomes assessed using RE-AIM framework [Срок оценки: 3 years]

Критерии участия

Критерии включения

  • pre-frail or robust older adults who can provide consent and follow instructions

Критерии исключения

  • frail or with terminal illness

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Сингапур · 1 центр
  • National University Hospital — Singapore

Идентификаторы

NCT: NCT07525583 · NICTran2023-0013 · NICTran2023-0013

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗