Effect of Bleaching Regimen With Different Activation Modes on Color Stability, Surface Roughness, Tooth Sensitivity and Patient Satisfaction

Обзор

The purpose of this study was to conduct a randomized double-blind clinical trial to examine the efficacy of an in-office bleaching regimen with varied activation modes on color stability, surface roughness, tooth sensitivity, and patient satisfaction.

Подробное описание

Tooth discoloration is a common esthetic concern that can negatively impact patients' self-confidence and quality of life. Contemporary restorative dentistry increasingly emphasizes minimally invasive approaches, with vital tooth bleaching emerging as a widely accepted, conservative treatment for managing extrinsic and intrinsic discoloration. The effectiveness of bleaching procedures primarily depends on the oxidative degradation of chromogenic compounds within dental hard tissues, leading to improved tooth color.

In-office bleaching techniques often incorporate various activation modes intended to enhance the efficacy of bleaching agents, accelerate treatment time, and improve clinical outcomes. These activation methods may include light-emitting diode (LED) systems, laser activation, or purely chemical activation without external energy sources. Despite their widespread use, the actual benefit of these activation modalities remains controversial, with conflicting evidence regarding their influence on bleaching effectiveness and associated adverse effects.

Вмешательства

• Другое 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) with Laser Activation
  Application of a 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) to the labial tooth surfaces, followed by activation using a dental laser according to the manufacturer's recommended parameters. The bleaching procedure is performed in a single clinical session under standardized conditions
• Другое 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) with LED/Light Activation
  Application of a 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) followed by activation using a dental light-curing unit or LED-based bleaching system, according to manufacturer instructions.
• Другое 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) - Chemical Activation Only
  Application of 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) without the use of external energy sources, allowing the material to act chemically according to manufacturer instructions.

Первичные конечные точки

• Color Change (ΔE) [Срок оценки: Baseline (pre-bleaching), immediately post-bleaching, 1 month, and 3 months post-treatment]

Вторичные конечные точки (3)

• Enamel Surface Roughness (Ra, µm) [Срок оценки: Baseline and immediately after bleaching procedure]
• Tooth Sensitivity [Срок оценки: Immediately after bleaching, 24 hours post-treatment, and up to 7 days post-treatment]
• Patient Satisfaction [Срок оценки: Immediately after treatment and at 3-month follow-up]

Критерии участия

Критерии включения

• Adults aged 20-35 years
• Individuals seeking esthetic improvement through tooth bleaching
• Good general and oral health, with no active periodontal disease
• Normal vital teeth (confirmed by clinical examination)

Критерии исключения

• Teeth with caries, cracks, hypersensitivity, restorations, veneers, or crowns in the anterior region
• Pregnant or lactating women
• Smoking or use of tobacco products

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Лечение

Центры проведения

Египет · 1 центр

• Restorative Department, Faculty of Dentistry, Tanta University — Tanta

Публикации

• Pereira R, Silveira J, Dias S, Cardoso A, Mata A, Marques D. Bleaching efficacy and quality of life of different bleaching techniques - randomized controlled trial. Clin Oral Investig. 2022 Dec;26(12):7167-7177. doi: 10.1007/s00784-022-04678-5. Epub 2022 Aug 17. PMID 35976497
• Atay A, Canpolat D, Sismanoglu S, Usumez A. Comparative evaluation of different bleaching agents on the color stability, hardness and surface roughness of indirect esthetic restorative materials with different manufacturing methods. BMC Oral Health. 2025 Dec 4;26(1):36. doi: 10.1186/s12903-025-07355-7. PMID 41340117
• Alkhuzaie AI, Elawsya ME, Elkholany NR. Impact of Different Bleaching Methods on Surface Roughness, Microhardness, and Tooth-Restoration Interface of Ormocer- and Methacrylate-based Restorative Systems. J Clin Exp Dent. 2025 Apr 1;17(4):e422-e431. doi: 10.4317/jced.62614. eCollection 2025 Apr. PMID 40375839
• Jiang NW, Cheng YL, Huang HL, Zhong BJ, Bi W, Yu H. Correlation between patient satisfaction and color changes after tooth bleaching. J Esthet Restor Dent. 2024 Mar;36(3):437-444. doi: 10.1111/jerd.13200. Epub 2024 Feb 1. PMID 38303586
• Kurucu Karadeniz BK. Effects of different bleaching methods on the color stability, microhardness, and surface roughness of single-shade composites. BMC Oral Health. 2025 Dec 12;25(1):1895. doi: 10.1186/s12903-025-07147-z. PMID 41387842

Идентификаторы

NCT: NCT07493941 · Dental Bleaching

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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