Идёт набор NCT07483710

Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study

Без фазы С лечением Septic Shock

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Evaluation of muscle dysfunction in intensive care units for septic schock patients.
Кому может быть актуально: Состояния в реестре: Septic Shock. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle impairment. In the intensive care setting, quantitative and qualitative assessment of muscle function is challenging due to critical care environments (general anesthesia, altered consciousness, etc.). CT scan measurement at the 3rd lumbar level has been proposed to evaluate muscle function. Recent retrospective studies have highlighted increased mortality among patients with muscle mass impairment and/or decreased muscle density.

Подробное описание

To date, no prospective study has assessed the prognostic value of CT scan measurements of muscle function upon admission to intensive care units for patients treated for septic shock. That is the aim of this project.

Вмешательства

Другое Evaluation of muscle dysfunction in intensive care units for septic schock patients
Correlation between muscle L3 CT scan muscle derived parameters of muscle function upon intensive care unit admission and 3 months mortality after ICU discharge for patients admitted for septic shock

Первичные конечные точки

vital status [Срок оценки: 90 days]
Total muscle mass measured at L3 (cm²/m² ) [Срок оценки: at inclusion]
Total muscle density measured at L3 ( Hounsfield Unit) [Срок оценки: at inclusion]
Total fat excretion fraction measured at L3 (%) [Срок оценки: at inclusion]

Вторичные конечные точки (7)

SOFA (Sequential Organ Failure Assessment) severity score [Срок оценки: at inclusion, 10 days.]
Kinetics of changes in muscle assessment [Срок оценки: Day 1, 10, 90]
Total fat excretion fraction measured at L3 (%) [Срок оценки: at inclusion, 10 days, 90 days]
Total muscle density measured at L3 ( Hounsfield Unit) [Срок оценки: at inclusion, 10 days, 90 days]
Total muscle mass measured at L3 (cm²/m² ) [Срок оценки: at inclusion, 10 days, 90 days]
MRC score (Medical Research Council) [Срок оценки: at discharge from intensive care, 90 days]
Handgrip test (Kg) [Срок оценки: at discharge from intensive care, 90 days]

Критерии участия

Критерии включения

Patients hospitalized in intensive care for septic shock defined by the presence of a documented or suspected infection, plasma lactate >2 mmol/L, and an increase in SOFA score of more than 2 points from baseline (Singer et al., 2016)

Patients who underwent a non-contrast CT scan within 48 hours prior to admission and up to 24 hours after admission to intensive care
Patients affiliated with or eligible for social security