Prehab for Pancreatic Cancer Surgery

This is a single-center, prospective pilot study designed to evaluate the implementation of a standardized, multimodal prehabilitation program delivered during neoadjuvant chemotherapy prior to pancreatic cancer surgery. The intervention is integrated into routine preoperative care and includes coordinated physical activity, nutritional optimization, and supportive care components delivered throughout the neoadjuvant treatment period. Assessments are performed at baseline, after completion of the prehabilitation period and before surgery, and approximately one month after surgery to characterize participation, intervention delivery, and perioperative changes in functional and clinical measures.

Data collection includes standardized functional fitness assessments, patient-reported surveys, and abstraction of perioperative clinical data from the electronic medical record. Analyses are descriptive and exploratory, reflecting the pilot nature of the study, and are intended to characterize feasibility, adherence, and variability of measured outcomes rather than to test efficacy. Findings from this study will be used to refine intervention delivery, identify logistical and patient-level barriers, and inform the design of future larger-scale studies evaluating prehabilitation in pancreatic cancer surgery.

• Change in 6-minute walk distance [Срок оценки: Baseline enrollment (pre-prehabilitation) to preoperative assessment (after completion of prehabilitation) up to 6 months after enrollment.]
• Change in Fried Frailty phenotype between enrollment and pre-operative evaluation [Срок оценки: Enrollment to preoperative assessment (up to 6 months after enrollment)]
• Change in nutritional status using the Patient Generated-Subjective Global Assessment (PG-SGA) [Срок оценки: Baseline, preoperative assessment, postoperative follow up (up to 1 year after enrollment)]
• Change in body mass index (BMI) [Срок оценки: Enrollment, preoperative assessment, through postoperative follow up, up to 1 year after enrollment]
• Change in physical functioning measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 10a [Срок оценки: Baseline, preoperative assessment, postoperative follow up (up to 1 year after enrollment)]
• Change in health related quality of life measured by change in Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) score [Срок оценки: Baseline, preoperative assessment, postoperative follow up (up to 1 year after enrollment)]
• Postoperative complications measured using Clavien-Dindo classification [Срок оценки: Up to 30 days after surgery (up to 1 year after enrollment)]
• Postoperative hospital length of stay [Срок оценки: Up to 90 days postoperative (up to 14 months after enrollment)]