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Набор скоро начнётся NCT07466706

Levator Muscle and Its Aponeurotic Maldevelopment in Congenital Ptosis

Без фазы С лечением Congenital Ptosis

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: levator muscle resection.
Кому может быть актуально
Состояния в реестре: Congenital Ptosis. Базовые параметры: Без ограничений · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Египет
Следующий шаг
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Официальное название

Maldevelopment Of Levator Muscle And Its Aponeurosis In Simple Congenital Ptosis: Clinical, Surgical And Histopathological Analysis

Обзор

this study reports the incidence of levator muscle dysgenesis among patients with simple congenital myogenic ptosis. In addition, the study aims to describ the nature of the dysgenesis, including the gross appearance of the muscle intraoperatively as well as the histopathological features under the microscope, correlation between the degree of dysgenesis and the preoperative ptosis assessment, and evaluation of the surgical outcome after levator muscle resection. Also, this research aims to shed light on the role of aponeurotic developmental anomalies, specifically fibrotic changes and maldevelopment in the pathogenesis of simple congenital ptosis.

Подробное описание

Despite the general agreement on the myogenic etiology of simple congenital ptosis, the exact pathogenesis of the levator palpebrae superioris (LPS) muscle remains controversial. This debate stems from confusing pathological changes within the LPS; while childhood ptosis is commonly attributed to muscle dystrophy , other reports have identified criteria consistent with dysgenesis. Consequently, the majority of published literature has focused on these muscle belly changes-supporting either the dysgenesis or dystrophy theories-or on neural etiologies in cases associated with superior rectus paresis or the Marcus Gunn jaw-winking phenomenon.

However, congenital ptosis may also arise from mechanical or aponeurotic factors which are frequently overlooked. Aponeurotic disinsertion or dehiscence is a well-recognized cause of acquired (involutional or traumatic) ptosis and is classically corrected by the repair technique first described by Quickert. While typically associated with adults, congenital aponeurotic defects do exist; Anderson and Gordy attributed these to a failure of the levator aponeurosis (LA) to correctly insert into the tarsus.

Despite this, reports exploring LA fibrotic changes in congenital cases remain scarce. Congenital aponeurotic maldevelopment is an estab- lished yet underreported entity of congenital ptosis. It could be suspected clinically with high crease position, lower lid position on downgaze and presence of corneal hue.

The investigators have observed fibrotic changes within the LA, or fibrous bands anchoring the LA to surrounding structures, during resection in patients with simple congenital ptosis.

Вмешательства

  • Процедура levator muscle resection
    All patients will undergo levator muscle resection under general anesthesia. A standard skin incision will be made through the eyelid crease and orbicularis muscle. The orbital septum will be opened to expose the preaponeurotic fat, which will be retracted to identify the Levator Aponeurosis (LA), Whitnall's ligament, and the Levator Palpebrae Superioris (LPS) muscle belly. * Macroscopic Assessment: Before resection, the LA and surrounding tissues will be meticulously inspected and photographed

Первичные конечные точки

  • Nature and Pattern of Levator Muscle Dysgenesis [Срок оценки: Preoperative clinical assessment compared with histopathological findings obtained at time of surgery.]

Критерии участия

Критерии включения

  • Unilateral or bilateral simple congenital ptosis

Критерии исключения

  • Previous eyelid or orbital surgery.
  • Acquired ptosis (traumatic, myogenic, or neurogenic).
  • Complex congenital ptosis (e.g., Marcus Gunn jaw-winking phenomenon, Blepharophimosis syndrome).
  • Poor or inverted Bell's phenomenon

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Не применимо
Модель
Одна группа
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Египет · 1 центр
  • AssiuyU — Asyut

Публикации

  • Alahmadawy YA, Ahmed RA. Congenital ptosis with aponeurotic maldevelopment: clinical and surgical perspectives : Aponeurotic maldevelopment in congenital ptosis. Int Ophthalmol. 2024 Mar 2;44(1):123. doi: 10.1007/s10792-024-03053-5. PMID 38429587
  • Al-Faky YH. Surgical Observations of the Levator Aponeurosis Fibrotic Changes in Simple Congenital Ptosis Suggest Complex Pathogenesis. Ophthalmic Plast Reconstr Surg. 2021 Jul-Aug 01;37(4):329-333. doi: 10.1097/IOP.0000000000001860. PMID 33156145
  • Alahmadawy YA, Ahmed RA, Allen RC, Diab MM. Levator Muscle Complex Exploration During Surgery for Simple Severe Congenital Ptosis. Ophthalmic Plast Reconstr Surg. 2026 Jan-Feb 01;42(1):90-96. doi: 10.1097/IOP.0000000000003015. Epub 2025 Aug 26. PMID 40856211
  • Baldwin HC, Manners RM. Congenital blepharoptosis: a literature review of the histology of levator palpebrae superioris muscle. Ophthalmic Plast Reconstr Surg. 2002 Jul;18(4):301-7. doi: 10.1097/01.IOP.0000021973.72318.07. PMID 12142765

Идентификаторы

NCT: NCT07466706 · congenital ptosis

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗