Набор скоро начнётся NCT07462104

Metabolic Syndrome Associated Diet

— Наблюдательное Metabolic Syndrome (MetS) Periodontitis Diet, Food and Nutrition

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально: Состояния в реестре: Metabolic Syndrome (MetS), Periodontitis, Diet, Food and Nutrition. Базовые параметры: 18 лет — 65 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Turkey (Türkiye)
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Pro-İnflammatory Diet as a Modifying Factor in Periodontal Tissue Destruction Associated With Metabolic Syndrome

Обзор

The goal of this observational study is to examine the relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate the role of the Dietary Inflammatory Index (DII) in this association. The main question it aims to answer is: Does a pro-inflammatory diet, as measured by the DII, increase the risk or severity of periodontitis in individuals with metabolic syndrome? Participants will include adults who meet the diagnostic criteria for metabolic syndrome. Their periodontal health will be assessed through standard clinical parameters, and dietary data will be collected using a validated food frequency questionnaire to calculate individual DII scores. The study will observe and analyze these factors to explore potential links between diet-induced inflammation, systemic metabolic health, and periodontal outcomes.

Подробное описание

This study aims to investigate the potential relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate this association through the Dietary Inflammatory Index (DII), which reflects the inflammatory potential of diet. Periodontal status will be assessed using clinical parameters (plaque index, probing pocket depth, clinical attachment loss, and gingival bleeding). MetS diagnosis will be based on criteria such as waist circumference, fasting glucose level, serum triglycerides, HDL cholesterol, and blood pressure. Dietary habits of participants will be analyzed using a validated food frequency questionnaire, and individual DII scores will be calculated. The data obtained will be used to evaluate the effects of dietary inflammatory load on systemic metabolic parameters and periodontal health. This study will aim to provide scientific evidence on the role of anti-inflammatory dietary strategies in periodontal and metabolic health.

Первичные конечные точки

Dietary Inflammatory Index [Срок оценки: Day 1]

Вторичные конечные точки (5)

Clinical Periodontal Parameters (Plaque Index) [Срок оценки: Day 1]
Clinical Periodontal Parameters (Gingival Index) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Bleeding on Probing Index) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Probing Pocket Depth) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Clinical Attachment Loss) [Срок оценки: Day 1]

Критерии участия

Критерии включения

Being between 18 and 65 years of age
Presence of at least three of the following parameters: (For MetS diagnosis) Waist circumference: ≥ 94 cm for men, ≥ 88 cm for women Blood pressure ≥ 130/85 mmHg or taking antihypertensive medication Fasting blood glucose ≥ 100 mg/dl or diagnosed with Type 2 Diabetes Triglycerides ≥ 1.7 mmol/L HDL < 1.29 mmol/L
Having at least 20 teeth
Not having received periodontal therapy in the last 6 months
Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
Not having any autoimmune disease, osteoporosis, or cancer
Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates
Not being pregnant
Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
Not taking antioxidant supplements in the last 6 months