Идёт набор NCT07449117

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Без фазы С лечением Mild Cognitive Impairment (MCI) Amnestic Lewy Body Disease With Mild Cognitive Impairment Parkinson's Disease With Mild Cognitive Impairment

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Active Temporal Interference Stimulation (TIS), Placebo / Sham TIS.
Кому может быть актуально: Состояния в реестре: Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment. Базовые параметры: 60 лет — 80 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Чехия
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases

Обзор

The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.

Подробное описание

The study aims to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the deep structures of the fronto-striatal circuit involved in language processing. The research focuses on patients with neurodegenerative diseases who often suffer from communication deficits and impaired sentence comprehension.

Participants will undergo a cross-over design consisting of a single session of active TIS directed at the striatum and a session of placebo stimulation. The stimulation will be administered in a randomized order. The duration of the stimulation is approximately 20 minutes. During the stimulation, participants will perform a sentence comprehension task. Resting-state fMRI measurements will be taken before and after the stimulation to evaluate offline effects on brain connectivity and potential neuroplasticity.

Вмешательства

Устройство Active Temporal Interference Stimulation (TIS)
Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.
Устройство Placebo / Sham TIS
Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.

Первичные конечные точки

Changes in Task-Related Brain Activation [Срок оценки: Immediately following the 20-minute stimulation session (approximately 0 to 30 minutes post-stimulation).]
Changes in Resting-State Functional Connectivity [Срок оценки: Immediately following the 20-minute stimulation session (approximately 0 to 30 minutes post-stimulation).]
Behavioral Performance in Sentence Comprehension Task [Срок оценки: During the approximately 20-minute stimulation intervention.]

Критерии участия

Критерии включения

Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).