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Набор по приглашению NCT07444736

Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity

Без фазы С лечением Obesity & Overweight

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Intervention, Intervention.
Кому может быть актуально
Состояния в реестре: Obesity & Overweight. Базовые параметры: 18 лет — 30 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Мексика
Следующий шаг
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Обзор

To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.

Подробное описание

Resistance training has been demonstrated to be an effective intervention for improving muscular strength and metabolic profile. According to the available evidence, a moderate-to-high intensity level (60-90% of one-repetition maximum \[1RM\]) is required to achieve optimal outcomes in healthy adults.

Blood flow restriction (BFR) training, in turn, has emerged as an innovative strategy that promotes gains comparable or similar to those achieved with moderate-to-high intensity resistance training. It has been proposed as an efficient and safe training alternative in both clinical and non-clinical settings . Current findings identify BFR as a promising, versatile, accessible, and particularly useful tool when moderate-to-high intensity resistance training must be limited or contraindicated.

Therefore, the present study aims to evaluate the effects of 8 weeks of resistance training combined with blood flow restriction on muscular strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity, providing evidence regarding a potentially safe and effective intervention.

Вмешательства

  • Другое Intervention
    The BFR group will perform machine-based quadriceps extension exercises and dumbbell biceps curls involving both lower limbs and both upper limbs. Each exercise will consist of 4 sets of 12 repetitions. Quadriceps extensions will be performed at an intensity of 40% of one-repetition maximum (1RM), and biceps curls at 20% of 1RM. The execution cadence will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase. Inter-set rest intervals will be 1 minute. For vas
  • Другое Intervention
    The control group will perform quadriceps extensions and biceps curls, completing 4 sets of 10 repetitions at an intensity of 70% of one-repetition maximum (1RM). The execution tempo will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase, with 2-minute inter-set rest intervals. The protocol will adhere to the resistance training guidelines established by the American College of Sports Medicine (ACSM)

Первичные конечные точки

  • Muscle strength [Срок оценки: Baseline and after 8 weeks]
  • Dynamic muscle strength [Срок оценки: Baseline and after 8 weeks]
  • Arm circumference [Срок оценки: Baseline and after 8 weeks]
  • Thigh circumference [Срок оценки: Baseline and after 8 weeks]
  • Maximum oxygen uptake (VO₂max) [Срок оценки: Baseline and after 8 weeks]
  • Systolic blood pressure (SBP) [Срок оценки: Baseline and after 8 weeks]
  • Diastolic blood pressure (DBP) [Срок оценки: Baseline and after 8 weeks]
  • Heart rate [Срок оценки: Baseline and after 8 weeks]
  • Glucose [Срок оценки: Baseline and after 8 weeks]
  • Triglycerides [Срок оценки: Baseline and after 8 weeks]

Критерии участия

Критерии включения

  • Adults aged 18 to 40
  • Both genders
  • BMI ≥ 30 kg/m\^2 and < 40 kg/m\^2
  • Signed informed consent form

Критерии исключения

  • Participants who smoke
  • Personal and family history of vascular disease or deep vein thrombosis
  • Clinical diagnosis of hypothyroidism
  • Clinical diagnosis of type 1 diabetes mellitus
  • Clinical diagnosis of type 2 diabetes mellitus
  • Clinical diagnosis of grade 3 obesity
  • Clinical diagnosis of hypertension
  • Clinical diagnosis of acute myocardial infarction or angina pectoris
  • Use of nitrates and calcium channel blockers within 4 days prior to the start of the study
  • Use of anticoagulants
  • Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention
  • Pregnant women
  • Breastfeeding women
  • Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day
  • Postural and biomechanical disorders (knee, foot, and spine)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Рандомизированное
Модель
Параллельные группы
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Мексика · 1 центр
  • Centro Universitario de Tlajomulco — Tlajomulco de Zúñiga

Идентификаторы

NCT: NCT07444736 · CUTLAJO260219

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗